Early immune factors associated with the development of post-acute sequelae of SARS-CoV-2 infection in hospitalized and non-hospitalized individuals

被引:2
|
作者
Leung, Jacqueline M. [1 ]
Wu, Michelle J. [1 ]
Kheradpour, Pouya [1 ]
Chen, Chen [1 ]
Drake, Katherine A. [1 ]
Tong, Gary [1 ]
Ridaura, Vanessa K. [1 ]
Zisser, Howard C. [1 ]
Conrad, William A. [2 ]
Hudson, Natalia [3 ]
Allen, Jared [3 ]
Welberry, Christopher [3 ]
Parsy-Kowalska, Celine [3 ]
Macdonald, Isabel [3 ]
Tapson, Victor F. [4 ]
Moy, James N. [5 ]
deFilippi, Christopher R. [6 ]
Rosas, Ivan O. [7 ]
Basit, Mujeeb [8 ]
Krishnan, Jerry A. [9 ]
Parthasarathy, Sairam [10 ]
Prabhakar, Bellur S. [11 ]
Salvatore, Mirella [12 ,13 ]
Kim, Charles C. [1 ]
机构
[1] Verily Life Sci, South San Francisco, CA 94080 USA
[2] Providence Little Co, Mary Med Ctr, Torrance, CA USA
[3] Oncimmune Ltd, Nottingham, England
[4] Cedars Sinai Med Ctr, Dept Med, Los Angeles, CA USA
[5] Rush Univ, Dept Internal Med, Med Ctr, Chicago, IL USA
[6] Inova Schar Heart & Vasc, Falls Church, VA USA
[7] Baylor Coll Med, Dept Med, Houston, TX USA
[8] Univ Texas Southwestern Med Ctr, Dept Internal Med, Dallas, TX USA
[9] Univ Illinois, Breathe Chicago Ctr, Chicago, IL USA
[10] Univ Arizona, Div Pulm Allergy Crit Care & Sleep Med, Tucson, AZ USA
[11] Univ Illinois, Coll Med, Dept Microbiol & Immunol, Chicago, IL USA
[12] Dept Med, Weill Cornell Med, New York, NY USA
[13] Weill Cornell Med, Dept Populat Hlth Sci, New York, NY USA
来源
FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷
关键词
COVID-19; PASC; long COVID; autoantibody; double-negative B cells; T-CELL-ACTIVATION; SEVERE COVID-19; B-CELLS; MILD; RESPONSES; PROTEIN; HEALTH;
D O I
10.3389/fimmu.2024.1348041
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background Infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to post-acute sequelae of SARS-CoV-2 (PASC) that can persist for weeks to years following initial viral infection. Clinical manifestations of PASC are heterogeneous and often involve multiple organs. While many hypotheses have been made on the mechanisms of PASC and its associated symptoms, the acute biological drivers of PASC are still unknown.Methods We enrolled 494 patients with COVID-19 at their initial presentation to a hospital or clinic and followed them longitudinally to determine their development of PASC. From 341 patients, we conducted multi-omic profiling on peripheral blood samples collected shortly after study enrollment to investigate early immune signatures associated with the development of PASC.Results During the first week of COVID-19, we observed a large number of differences in the immune profile of individuals who were hospitalized for COVID-19 compared to those individuals with COVID-19 who were not hospitalized. Differences between individuals who did or did not later develop PASC were, in comparison, more limited, but included significant differences in autoantibodies and in epigenetic and transcriptional signatures in double-negative 1 B cells, in particular.Conclusions We found that early immune indicators of incident PASC were nuanced, with significant molecular signals manifesting predominantly in double-negative B cells, compared with the robust differences associated with hospitalization during acute COVID-19. The emerging acute differences in B cell phenotypes, especially in double-negative 1 B cells, in PASC patients highlight a potentially important role of these cells in the development of PASC.
引用
收藏
页数:13
相关论文
共 50 条
  • [1] Markers of immune activation and inflammation in individuals with post-acute sequelae of SARS-CoV-2 infection
    Peluso, M.
    Lu, S.
    Tang, A.
    Durstenfeld, M. S.
    Ho, H.
    Goldberg, S. A.
    Forman, C. A.
    Munter, S. E.
    Hoh, R.
    Tai, V.
    Chenna, A.
    Yee, B. C.
    Winslow, J. W.
    Petropoulos, C. J.
    Greenhouse, B.
    Hunt, P. W.
    Hsue, P. Y.
    Martin, J. N.
    Kelly, J. D.
    Glidden, D. V.
    Deeks, S. G.
    Henrich, T. J.
    ANTIVIRAL THERAPY, 2021, 26 : 14 - 15
  • [2] Early biological markers of post-acute sequelae of SARS-CoV-2 infection
    Lu, Scott
    Peluso, Michael J.
    Glidden, David V.
    Davidson, Michelle C.
    Lugtu, Kara
    Pineda-Ramirez, Jesus
    Tassetto, Michel
    Garcia-Knight, Miguel
    Zhang, Amethyst
    Goldberg, Sarah A.
    Chen, Jessica Y.
    Fortes-Cobby, Maya
    Park, Sara
    Martinez, Ana
    So, Matthew
    Donovan, Aidan
    Viswanathan, Badri
    Hoh, Rebecca
    Donohue, Kevin
    McIlwain, David R.
    Gaudiliere, Brice
    Anglin, Khamal
    Yee, Brandon C.
    Chenna, Ahmed
    Winslow, John W.
    Petropoulos, Christos J.
    Deeks, Steven G.
    Briggs-Hagen, Melissa
    Andino, Raul
    Midgley, Claire M.
    Martin, Jeffrey N.
    Saydah, Sharon
    Kelly, J. Daniel
    NATURE COMMUNICATIONS, 2024, 15 (01)
  • [3] Pediatric Post-Acute Sequelae of SARS-CoV-2 infection
    Jason, Leonard A. A.
    Johnson, Madeline
    Torres, Chelsea
    FATIGUE-BIOMEDICINE HEALTH AND BEHAVIOR, 2023, 11 (2-4): : 55 - 65
  • [4] Neurological post-acute sequelae of SARS-CoV-2 infection
    Takao, Masaki
    Ohira, Masayuki
    PSYCHIATRY AND CLINICAL NEUROSCIENCES, 2023, 77 (02) : 72 - 83
  • [5] Early biomarkers in hospitalized patients as predictors of post-acute sequelae of SARS-CoV-2 infection: a one-year cohort study
    Nair, Chithira V.
    Krishnakumar, Malavika
    Gutjahr, Georg
    Kulirankal, Kiran G.
    Moni, Merlin
    Sathyapalan, Dipu T.
    BMC INFECTIOUS DISEASES, 2025, 25 (01)
  • [6] Clinical and demographic predictors of post-acute sequelae of COVID-19 (PASC) in non-hospitalized individuals
    Reynolds, William
    Abril, Isabel
    Saberwal, Simran
    Arnold, Steven
    Guzman-Velez, Edmarie
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2023, 455
  • [7] The Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 infection
    Moghimi, Narges
    Di Napoli, Mario
    Biller, Jose
    Siegler, James E.
    Shekhar, Rahul
    McCullough, Louise D.
    Harkins, Michelle S.
    Hong, Emily
    Alaouieh, Danielle A.
    Mansueto, Gelsomina
    Divani, Afshin A.
    CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS, 2021, 21 (09)
  • [8] The Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection
    Narges Moghimi
    Mario Di Napoli
    José Biller
    James E. Siegler
    Rahul Shekhar
    Louise D. McCullough
    Michelle S. Harkins
    Emily Hong
    Danielle A. Alaouieh
    Gelsomina Mansueto
    Afshin A. Divani
    Current Neurology and Neuroscience Reports, 2021, 21
  • [9] Neuroimaging markers of cognitive fatigue in individuals with post-acute sequelae of SARS-CoV-2 infection
    Niemczak, Christopher E.
    Ford, James C.
    Roth, Robert M.
    Leigh, Samantha M.
    Parsonnet, Jeffrey
    Martin, Christina
    Soule, Shreve O.
    Haron, Theresa M.
    Buckey Jr, Jay C.
    Wylie, Glenn R.
    BRAIN AND COGNITION, 2025, 183
  • [10] Prevalence and characteristics of post-acute sequelae of SARS-CoV-2 (PASC) in non-hospitalized persons with COVID-19 enrolled in a clinical trial of early treatment (ACTIV-2)
    Evering, T. H.
    Sanusi, B.
    Jilg, N.
    Yeh, E.
    Moser, C.
    Ritz, J.
    Wohl, D.
    Daar, E. S.
    Klekotka, P.
    Javan, A. C.
    Eron, J. J.
    Currier, J.
    Hughes, M.
    Smith, D.
    Chew, K. W.
    ANTIVIRAL THERAPY, 2021, 26 : 8 - 8