Nationwide epidemiologic and genetic surveillance of hepatitis E in Japan, 2014-2021

被引：3

作者：

Sugiyama, Ryuichi ^{[1
]}

Takahara, Osamu ^{[2
]}

Yahata, Yuichiro ^{[3
]}

Kanou, Kazuhiko ^{[3
,4
]}

Nagashima, Mami ^{[5
]}

Kiyohara, Tomoko ^{[1
]}

Li, Tian-Cheng ^{[1
]}

Arima, Yuzo ^{[2
]}

Shinomiya, Hiroto ^{[6
]}

Ishii, Koji ^{[4
]}

Muramatsu, Masamichi ^{[1
,7
]}

Suzuki, Ryosuke ^{[1
,8
,9
]}

机构：

[1] Natl Inst Infect Dis, Dept Virol 2, Tokyo, Japan

[2] Natl Inst Infect Dis, Ctr Surveillance Immunizat & Epidemiol Res, Tokyo, Japan

[3] Natl Inst Infect Dis, Ctr Field Epidem Intelligence Res & Profess Dev, Tokyo, Japan

[4] Natl Inst Infect Dis, Dept Qual Assurance Radiat Safety & Informat Manag, Tokyo, Japan

[5] Tokyo Metropolitan Inst Publ Hlth, Dept Microbiol, Tokyo, Japan

[6] Ehime Prefectural Inst Publ Hlth & Environm Sci, Matsuyama, Ehime, Japan

[7] Fdn Biomed Res & Innovat Kobe, Dept Infect Dis Res, Kobe, Japan

[8] Tokyo Univ Sci, Dept Biol Sci & Technol, Tokyo, Japan

[9] Natl Inst Infect Dis, Dept Virol 2, 4-7-1 Gakuen, Tokyo 2080011, Japan

来源：

JOURNAL OF MEDICAL VIROLOGY | 2023年 / 95卷 / 06期

基金：

日本学术振兴会;

关键词：

genotype; hepatitis E virus; Japan; nationwide surveillance; subtype; E VIRUS-INFECTION; STRAINS; GENOME; SWINE; IDENTIFICATION; GENOTYPES; SEQUENCE; ORIGIN;

D O I：

10.1002/jmv.28886

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hepatitis E virus (HEV) is an emerging causative agent of acute hepatitis. To clarify the epidemiology of HEV and characterize the genetic diversity of the virus in Japan, nationwide enhanced surveillance and molecular characterization studies of HEV in Japan were undertaken from 2014 to 2021. In total, 2770 hepatitis E cases were reported, of which 88% were domestic cases, while only 4.1% represented cases following infection abroad. In addition, 57% of domestic infections occurred in males aged in their 40s-70s. For domestic cases, infection via pork meat consumption continued to be the most reported route. Analysis of the 324 sequences detected between 2016 and 2021 showed that the majority of domestic HEV strains belong to Genotype 3a (G3a) and G3b. In contrast, six of eight cases of G1 HEV reflected infection abroad. Our results suggest that HEV is circulating widely in Japan, with genotypes G3a and G3b being most prevalent. Continued surveillance is necessary to monitor future trends and changes in the epidemiology of HEV in Japan.

引用

页数：9

共 44 条

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