Ex Vivo Mathematical Myeloma Advisor (EMMA) - a Clinical, Molecular, and Phenotypic Platform to Tailor Personalized Therapeutic Strategies for Multiple Myeloma

被引：0
|
作者：
Renatino-Canevarolo, Rafael [1 ]
Silva, Maria [1 ]
Meads, Mark B. [2 ]
Zhao, Xiaohong [2 ]
Achille, Alexandra [2 ]
Noyes, David [2 ]
Sudalagunta, Praneeth Reddy [1 ]
Alugubelli, Raghunandan Reddy [2 ]
Lastorino, Daniel [3 ]
Tordesillas, Leticia [4 ]
Fontela, Miguel Gomez [4 ]
Hampton, Oliver [5 ]
Abate-Daga, Daniel [4 ]
Shain, Kenneth H. [2 ]
Silva, Ariosto Siqueira [1 ]
机构：
[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Metab & Physiol, Tampa, FL USA
[2] H Lee Moffitt Canc Ctr & Res Inst, Dept Malignant Hematol, Tampa, FL USA
[3] H Lee Moffitt Canc Ctr & Res Inst, NTRO Clin Res Operat, Tampa, FL USA
[4] H Lee Moffitt Canc Ctr & Res Inst, Dept Immunol, Tampa, FL USA
[5] Aster Insights, Sci & Innovat Div, Tampa, FL USA
来源：
BLOOD | 2023年 / 142卷
关键词：
D O I：
10.1182/blood-2023-190479
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
803
引用
收藏
页数：3
相关论文
共 24 条
  • [1] Ex vivo drug response heterogeneity reveals personalized therapeutic strategies for patients with multiple myeloma
    Kropivsek, Klara
    Kachel, Paul
    Goetze, Sandra
    Wegmann, Rebekka
    Festl, Yasmin
    Severin, Yannik
    Hale, Benjamin D.
    Mena, Julien
    van Drogen, Audrey
    Dietliker, Nadja
    Tchinda, Joelle
    Wollscheid, Bernd
    Manz, Markus G.
    Snijder, Berend
    [J]. NATURE CANCER, 2023, 4 (05) : 734 - +
  • [2] Ex vivo drug response heterogeneity reveals personalized therapeutic strategies for patients with multiple myeloma
    Klara Kropivsek
    Paul Kachel
    Sandra Goetze
    Rebekka Wegmann
    Yasmin Festl
    Yannik Severin
    Benjamin D. Hale
    Julien Mena
    Audrey van Drogen
    Nadja Dietliker
    Joëlle Tchinda
    Bernd Wollscheid
    Markus G. Manz
    Berend Snijder
    [J]. Nature Cancer, 2023, 4 : 734 - 753
  • [3] An Ex Vivo Platform for the Prediction of Clinical Response in Multiple Myeloma
    Silva, Ariosto
    Silva, Maria C.
    Sudalagunta, Praneeth
    Distler, Allison
    Jacobson, Timothy
    Collins, Aunshka
    Tuan Nguyen
    Song, Jinming
    Chen, Dung-Tsa
    Chen, Lu
    Cubitt, Christopher
    Baz, Rachid
    Perez, Lia
    Rebatchouk, Dmitri
    Dalton, William
    Greene, James
    Gatenby, Robert
    Gillies, Robert
    Sontag, Eduardo
    Meads, Mark B.
    Shain, Kenneth H.
    [J]. CANCER RESEARCH, 2017, 77 (12) : 3336 - 3351
  • [4] Ex Vivo Patient-Specific Validation Of Personalized Therapeutic Designed For Multiple Myeloma
    Doudican, Nicole A.
    Vali, Shireen
    Kapoor, Shweta
    Talawdekar, Anay
    Sultana, Zeba
    Alam, Aftab
    Kumar, Ansu
    Singh, Neeraj Kumar
    Tyagi, Anuj
    Abbasi, Taher
    Mazumder, Amitabha
    [J]. BLOOD, 2013, 122 (21)
  • [5] Ex vivo modeling of multiple myeloma: A novel drug sensitivity screening platform
    Sambandam, Vaishnavi
    Inamdar, Sharvari
    Hsu, Haoting
    Walling, Brandon
    Schiviani, Paolo
    Andar, Abhay
    Zipeto, Marianna
    Ritchie, Michael
    Heidemann, Karin Abarca
    Mancini, Maria
    [J]. CANCER RESEARCH, 2023, 83 (07)
  • [6] Integration of Ex Vivo Drug Testing and in-Depth Molecular Profiling Reveals Oncogenic Signaling Pathways and Novel Therapeutic Strategies for Multiple Myeloma
    Majumder, Muntasir Mamun
    Silvennoinen, Raija
    Antilla, Pekka
    Tamborero, David
    Eldfors, Samuli
    Karjalainen, Riikka
    Kuusanmaki, Heikki
    Lievonen, Juha
    Parsons, Alun
    Suvela, Minna
    Saily, Marjanna
    Yadav, Bhagwan
    Wennerberg, Krister
    Kallioniemi, Olli
    Porkka, Kimmo
    Heckman, Caroline A.
    [J]. BLOOD, 2014, 124 (21)
  • [7] Ex-Vivo Testing Platform to Predict Clinical Response and Resistance to Proteosome Inhibitors, IMiDs and Daratumumab in Multiple Myeloma
    Marin, Constanza
    Nicola, Maribel
    Andino, Diego
    Laura Bernaschini, Maria
    Conrrero, Agustina
    Ferreira, Gimena
    Piaggio, Marisa
    Remaggi, Guillermina
    Sol Jarchum, Maria
    Jarchum, Gustavo
    Meneces Bustillo, Rodrigo
    de los Milagros Rossi, Blanca
    Jose Garcia, Juan
    Zaki, Tarek Ali
    Llorens, Candelaria
    Gatti, Gerardo
    Arroyo, Daniela
    Soria, Gaston
    [J]. BLOOD, 2023, 142
  • [8] Biomimetic Culture Platform for Ex Vivo Preservation of Patient-Derived Multiple Myeloma Cells
    Zilberberg, Jenny
    Zhang, Wenting
    Siegel, David S.
    Lee, Woo Y.
    [J]. CANCER RESEARCH, 2017, 77
  • [9] Ex vivo expanded autologous natural killer cells as a novel therapeutic approach in multiple myeloma
    Alici, Evren
    Sutlu, Tolga
    Bjokstrand, Bo
    Gilljam, Mari
    Stellan, Birgitta
    Nahi, Hareth
    Quezada, Hernan Concha
    Gahrton, Gosta
    Ljunggren, Hans-Gustaf
    Dilber, M. Sirac
    [J]. HUMAN GENE THERAPY, 2008, 19 (10) : 1183 - 1183
  • [10] Immune System Alterations in Multiple Myeloma: Molecular Mechanisms and Therapeutic Strategies to Reverse Immunosuppression
    Diaz-Tejedor, Andrea
    Lorenzo-Mohamed, Mauro
    Puig, Noemi
    Garcia-Sanz, Ramon
    Mateos, Maria-Victoria
    Garayoa, Mercedes
    Paino, Teresa
    [J]. CANCERS, 2021, 13 (06) : 1 - 26
123