Insight into the relevance of dinitrosyl iron complex (DNIC) formation in the absence of thiols in aqueous media

被引：0
|
作者：
Medeiros, Nathalia Miranda [1 ]
Garcia, Felipe Alves [1 ]
Truzzi, Daniela Ramos [1 ]
机构：
[1] Univ Sao Paulo, Dept Bioquim, Inst Quim, BR-05508000 Sao Paulo, Brazil
来源：
DALTON TRANSACTIONS | 2024年 / 53卷 / 05期
基金：
巴西圣保罗研究基金会;
关键词：
CELLULAR CHELATABLE IRON; ELECTRON-SPIN-RESONANCE; NITRIC-OXIDE; REVERSIBLE BINDING; CHEMISTRY; ACID; CONVERSION; KINETICS; EPR;
D O I：
10.1039/d3dt04356h
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
DNIC can be formed in aqueous media in the absence of thiols via mechanisms that depend exclusively on Fe(ii) and NO. However, these reactions do not take place at intracellular concentrations of Fe(ii) and NO, reinforcing the relevance of thiols to assist Fe(ii) to Fe(i) reduction during DNIC formation in biological media. A quantitative study of DNIC formation in the presence of non-thiol and thiol biomolecules in aqueous media points to the relevance of thiols to DNIC formation in cells.
引用
收藏
页码：1951 / 1955
页数：5
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