EIF4A1/2 INHIBITION DOWN-MODULATES THE OXIDATIVE STRESS RESPONSE AND PREVENTS LUNG METASTASIS IN OSTEOSARCOMA

被引：0
|
作者：
Lizardo, Michael [1 ]
Hughes, Christopher [1 ]
Huang, Yue [2 ]
Shyp, Taras [1 ]
Delaidelli, Alberto [1 ]
Zhang, Hai-Feng [1 ]
Shaool, Sol [3 ]
Sorensen, Poul [1 ]
机构：
[1] BC Canc Res Ctr, Dept Mol Oncol, Vancouver, BC, Canada
[2] BC Canc, Mol Oncol, Vancouver, BC, Canada
[3] Univ Victoria, Biochem & Chem, Victoria, BC, Canada
来源：
PEDIATRIC BLOOD & CANCER | 2023年 / 70卷
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
O099
引用
收藏
页码：S55 / S55
页数：1
相关论文
共 50 条
  • [1] A potent eIF4A1/2 inhibitor CR-1-31B down-modulates the antioxidant stress response in osteosarcoma cells and inhibits in vivo lung metastases
    Lizardo, Michael M.
    Hughes, Christopher
    Huang, Yue Zhou
    Delaidelli, Alberto
    Shyp, Taras
    Zhang, Haifeng
    Shaool, Sol Snir
    Sorensen, Poul H.
    CANCER RESEARCH, 2023, 83 (02)
  • [2] Pharmacologic Inhibition of EIF4A Blocks NRF2 Synthesis to Prevent Osteosarcoma Metastasis
    Lizardo, Michael M.
    Hughes, Christopher
    Huang, Yue Z.
    Shyp, Taras
    Delaidelli, Alberto
    Zhang, Hai-Feng
    Shaool, Sol Snir
    Renner, Annalena F.
    Burwag, Farez
    Sayles, Leanne C.
    Lee, Alex G.
    Sweet-Cordero, Alejandro
    Sorensen, Poul H.
    CLINICAL CANCER RESEARCH, 2024, 30 (19) : 4464 - 4481
  • [3] Adenylate kinase 4 modulates oxidative stress and stabilizes HIF-1 to drive lung adenocarcinoma metastasis
    Jan, Yi-Hua
    Lai, Tsung-Ching
    Yang, Chih-Jen
    Lin, Yuan-Feng
    Huang, Ming-Shyan
    Hsiao, Michael
    JOURNAL OF HEMATOLOGY & ONCOLOGY, 2019, 12 (1)
  • [4] Adenylate kinase 4 modulates oxidative stress and stabilizes HIF-1α to drive lung adenocarcinoma metastasis
    Yi-Hua Jan
    Tsung-Ching Lai
    Chih-Jen Yang
    Yuan-Feng Lin
    Ming-Shyan Huang
    Michael Hsiao
    Journal of Hematology & Oncology, 12
  • [5] Photo-oxidative stress down-modulates the activity of nuclear factor-κB via involvement of caspase-1, leading to apoptosis of photoreceptor cells
    Krishnamoorthy, RR
    Crawford, MJ
    Chaturvedi, MM
    Jain, SK
    Aggarwal, BB
    Al-Ubaidi, MR
    Agarwal, N
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (06) : 3734 - 3743
  • [6] Dipeptidyl peptidase-4 inhibition prevents lung injury in mice under chronic stress via the modulation of oxidative stress and inflammation
    Zhang, Shengming
    Li, Ping
    Xin, Minglong
    Jin, Xianglan
    Zhao, Longguo
    Nan, Yongshan
    Cheng, Xian Wu
    EXPERIMENTAL ANIMALS, 2021, 70 (04) : 541 - 552
  • [7] Sirt1 modulates Foxo-dependent transcription and prevents smooth muscle cell apoptosis in response to oxidative stress
    Sedding, D.
    Koenig, H.
    Tillmanns, H.
    EUROPEAN HEART JOURNAL, 2007, 28 : 796 - 796
  • [8] Sirt1 modulates foxo-dependent transcription and prevents smooth muscle cell apoptosis in response to oxidative stress
    Sedding, Daniel
    Koenig, Heike
    Krasteva, Gabriela
    Vogel, Sabina
    Tilmanns, Harald
    CIRCULATION, 2007, 116 (16) : 150 - 150
  • [9] Understanding the thermal response of rice eukaryotic transcription factor eIF4A1 towards dynamic temperature stress: insights from expression profiling and molecular dynamics simulation
    Singha, Dhanawantari L.
    Maharana, Jitendra
    Panda, Debashis
    Dehury, Budheswar
    Modi, Mahendra Kumar
    Singh, Salvinder
    JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2021, 39 (07): : 2575 - 2584
  • [10] OxyR2 Modulates OxyR1 Activity and Vibrio cholerae Oxidative Stress Response
    Wang, Hui
    Naseer, Nawar
    Chen, Yaran
    Zhu, Anthony Y.
    Kuai, Xuewen
    Galagedera, Nirupa
    Liu, Zhi
    Zhu, Jun
    INFECTION AND IMMUNITY, 2017, 85 (04)
12345