Cellular polyploidy in organ homeostasis and regeneration

被引：6

作者：

Fang, Juntao ^{[1
]}

de Bruin, Alain ^{[2
,3
]}

Villunger, Andreas ^{[4
,5
,6
]}

Schiffelers, Raymond ^{[7
]}

Lei, Zhiyong ^{[1
,7
]}

Sluijter, Joost P. G. ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Expt Cardiol, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands

[2] Univ Groningen, Dept Pediat, POB 30-001, NL-9700 RB Groningen, Netherlands

[3] Univ Utrecht, Dutch Mol Pathol Ctr, Dept Pathobiol, Yalelaan1, NL-3584 CL Utrecht, Netherlands

[4] Med Univ Innsbruck, Inst Dev Immunol, Bioctr, Innrain 80, A-6020 Innsbruck, Austria

[5] Ludwig Boltzmann Inst Rare & Undiagnosed Dis, Lazarettgasse 14,AKH BT 25-3 C-O CeMM Res Bldg,Hau, A-1090 Vienna, Austria

[6] CeMM Res Ctr Mol Med Austrian Acad Sci, Lazarettgasse 14,AKH BT 25-3, A-1090 Vienna, Austria

[7] Univ Med Ctr Utrecht, CDL Res, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands

来源：

PROTEIN & CELL | 2023年 / 14卷 / 08期

基金：

欧洲研究理事会;

关键词：

cellular polyploidy; tissue regeneration; cardiac regeneration; liver regeneration; MEDIATED ABSCISSION CHECKPOINT; POSTNATAL LIVER DEVELOPMENT; CARDIOMYOCYTE DNA-SYNTHESIS; TROPHOBLAST STEM-CELLS; IN-VIVO; HEPATOCYTE PLOIDY; CARDIAC MYOCYTES; PARTIAL-HEPATECTOMY; HEART REGENERATION; MAMMALIAN HEART;

D O I：

10.1093/procel/pwac064

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Polyploid cells, which contain more than one set of chromosome pairs, are very common in nature. Polyploidy can provide cells with several potential benefits over their diploid counterparts, including an increase in cell size, contributing to organ growth and tissue homeostasis, and improving cellular robustness via increased tolerance to genomic stress and apoptotic signals. Here, we focus on why polyploidy in the cell occurs and which stress responses and molecular signals trigger cells to become polyploid. Moreover, we discuss its crucial roles in cell growth and tissue regeneration in the heart, liver, and other tissues.

引用

页码：560 / 578

页数：19

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