BASELINE NUCLEOTIDE POLYMORPHISMS WITHIN HBV TARGET SITE IN CHRONIC HEPATITIS B SUBJECTS DO NOT IMPACT HBsAg REDUCTIONS MEDIATED BY RNA INTERFERENCE THERAPEUTIC AB-729

被引：0

作者：

Espiritu, Christine ^{[1
]}

Steuer, Holly M. Micolochick ^{[1
]}

Ardzinski, Andrzej ^{[1
]}

Sharma, Varun ^{[1
]}

Eley, Timothy ^{[1
]}

Sims, Karen ^{[1
]}

Lee, Amy C. H. ^{[1
]}

Rijnbrand, Rene ^{[1
]}

Cuconati, Andrea ^{[1
]}

Mani, Nagraj ^{[1
]}

Lam, Angela M. ^{[1
]}

Sofia, Michael J. ^{[1
]}

Thi, Emily P. ^{[1
]}

机构：

[1] Arbutus Biopharma, Warminster, PA USA

来源：

HEPATOLOGY | 2023年 / 78卷

关键词：

D O I：

暂无

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

1459-C

引用

页码：S560 / S560

页数：1

共 9 条

[1] Inhibition of hepatitis B surface antigen by RNA interference therapeutic AB-729 in chronic hepatitis B patients correlates with suppression of all HBsAg isoforms and HBV RNA
Thi, Emily P.
Yuen, Man-Fung
Gane, Edward
Sevinsky, Heather
Sims, Karen
Anderson, Mark
Lam, Angela M.
Sofia, Michael J.
Cloherty, Gavin
Picchio, Gaston
JOURNAL OF HEPATOLOGY, 2021, 75 : S760 - S761
[2] Inhibition of hepatitis B surface antigen in chronic hepatitis B subjects by RNA interference therapeutic AB-729 is accompanied by upregulation of HBV-specific T cell activation markers
Paratala, Bhavna
Park, Jang-June
Ganchua, Sharie C.
Gane, Edward
Yuen, Man-Fung
Lee, Amy C. H.
Moore, Chris
Lam, Angela M.
Sevinsky, Heather
Sims, Karen
Antoniello, Deana
Sofia, Michael J.
Picchio, Gaston
Thi, Emily P.
JOURNAL OF HEPATOLOGY, 2021, 75 : S761 - S761
[3] Inhibition of hepatitis B surface antigen by RNA interference therapeutic AB-729 is associated with increased cytokine signatures in HBV DNA plus chronic hepatitis B patients
Ganchua, Sharie C.
Paratala, Bhavna
Iott, Christina
Yuen, Man-Fung
Gane, Edward J.
Eley, Timothy
Sims, Karen
Gray, Kevin
Antoniello, Deana
Lam, Angela M.
Sofia, Michael J.
Picchio, Gaston
Thi, Emily P.
JOURNAL OF HEPATOLOGY, 2022, 77 : S850 - S850
[4] HBV TARGET SITE FOR THE RNA INTERFERENCE THERAPEUTIC IMDUSIRAN IS HIGHLY CONSERVED IN CHRONIC HEPATITIS B SUBJECTS
Espiritu, Christine
Ardzinski, Andrzej
Steuer, Holly Micolochick
Sharma, Varun
Gray, Kevin
Antoniello, Deana
Eley, Timothy
Sims, Karen
Cuconati, Andrea
Lam, Angela
Sofia, Michael
Thi, Emily
HEPATOLOGY, 2024, 80 : S316 - S316
[5] A single dose of the GalNAc-siRNA, AB-729, results in prolonged reductions in HBsAg, HBcrAg, HBV DNA and HBV RNA in the absence of nucleos (t)ide analogue therapy in HBeAg negative subjects with chronic hepatitis B infection
Gane, Edward
Sevinsky, Heather
Yuen, Man-Fung
Anderson, Mark
Cloherty, Gavin
Thi, Emily P.
Wattamwar, Tosh
Sofia, Michael J.
Gray, Kevin
Antoniello, Deana
Eley, Timothy
Picchio, Gaston
Sims, Karen
JOURNAL OF HEPATOLOGY, 2021, 75 : S762 - S763
[6] Repeat dosing of the GalNAc-siRNA AB-729 in subjects with chronic hepatitis B results in robust and sustained HBsAg suppression
Yuen, Man-Fung
Berliba, Elina
Sukeepaisarnjaroen, Wattana
Strasser, Simone
Tangkijvanich, Pisit
Holmes, Jacinta
Leerapun, Apinya
Jucov, Alina
Thi, Emily P.
Wattamwar, Tosh
Sofia, Michael J.
Sevinsky, Heather
Gray, Kevin
Antoniello, Deana
Eley, Timothy
Picchio, Gaston
Sims, Karen
Gane, Edward
JOURNAL OF HEPATOLOGY, 2021, 75 : S203 - S204
[7] Reduction of hepatitis B surface antigen mediated by RNA interference therapeutic AB-729 in chronic hepatitis B patients is associated with T cell activation and a decline in exhausted CD8 T cells
Ganchua, Sharie C.
Paratala, Bhavna
Iott, Christina
Gane, Edward J.
Yuen, Man-Fung
Eley, Timothy
Sims, Karen
Gray, Kevin
Antoniello, Deana
Lam, Angela M.
Sofia, Michael J.
Picchio, Gaston
Thi, Emily P.
JOURNAL OF HEPATOLOGY, 2022, 77 : S851 - S851
[8] LOW HBsAg LEVELS MAINTAINED FOLLOWING CESSATION OF THE GALNAC-siRNA, AB-729, IN CHRONIC HEPATITIS B SUBJECTS ON NUCLEOS(T)IDE ANALOGUE THERAPY
Yuen, Man Fung
Berliba, Elina
Sukeepaisarnjaroen, Wattana
Tangkijvanich, Pisit
Leerapun, Apinya
Holmes, Jacinta A.
Gane, Edward J.
Jucov, Alina
Thi, Emily P.
Sofia, Michael J.
Sevinsky, Heather
Eley, Timothy
Medvedeva, Elina
Gray, Kevin
Antoniello, Deana
Picchio, Gaston R.
Sims, Karen
Strasser, Simone I.
HEPATOLOGY, 2021, 74 (06) : 1402A - 1403A
[9] VIRAL SEQUENCE ANALYSIS OF NOT-CURRENTLY TREATED (NCT) CHRONIC HEPATITIS B (CHB) PATIENTS ENROLLED IN THE REEF-1 STUDY AND IMPACT OF BASELINE NUCLEOTIDE POLYMORPHISMS IN THE SMALL INTERFERING RNA (siRNA) JNJ-3989 TRIGGER TARGET REGIONS ON VIRAL ANTIGEN DECLINES
Verbinnen, Thierry
Jezorwski, John
Biermer, Michael
Shukla, Umesh
Augustyns, Ilse
Jacobson, Ira
Yuen, Man-Fung
De Meyer, Sandra
Lenz, Oliver
HEPATOLOGY, 2022, 76 : S321 - S322

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