Percutaneous Alginate Hydrogel Endomyocardial Injection with a Novel Dedicated Catheter Delivery System: An Animal Feasibility Study

被引：4

作者：

Wang, Bo ^{[1
,2
]}

Gao, Chao ^{[1
]}

Lim, Scott ^{[3
]}

Wang, Rutao ^{[1
]}

Zhu, Cun-jun ^{[1
]}

Onuma, Yoshinobu ^{[2
]}

Wang, Yunbing ^{[4
]}

Gao, Runlin ^{[5
]}

Serruys, Patrick W. J. C. ^{[2
]}

Lee, Randall J. ^{[6
]}

Tao, Ling ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian, Peoples R China

[2] Univ Galway, CORRIB Res Ctr Adv Imaging & Core Lab, Galway, Ireland

[3] Univ Virginia, Dept Med, Div Cardiovasc Med, Charlottesville, VA USA

[4] Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu, Sichuan, Peoples R China

[5] Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Beijing, Peoples R China

[6] Univ Calif San Francisco, Dept Med, San Francisco, CA 94115 USA

来源：

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | 2024年 / 17卷 / 04期

关键词：

Alginate hydrogel; Biomaterial; Percutaneous treatment; HEART-FAILURE; MYOCARDIAL-INFARCTION; IMPACT;

D O I：

10.1007/s12265-024-10497-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The objective of this preclinical study was to evaluate the feasibility and safety of transcatheter endocardial alginate hydrogel injection (TEAi) in a large animal model, utilizing the high-stiffness XDROP (R) alginate hydrogel in combination with the dedicated EndoWings (R) catheter-based system. All swine (n = 9) successfully underwent TEAi without complications. Acute results from a subset of animals (n = 5) demonstrated the ability of the catheter to access a wide range of endomyocardial areas and achieve consecutive circumferential hydrogel distribution patterns within the mid-left ventricular wall. Histological examinations at 6 months (n = 4) demonstrated that the XDROP (R) remained localized within the cardiac tissue. In addition, serial echocardiographic imaging showed that XDROP (R) had no adverse impacts on LV systolic and diastolic functions. In conclusion, this innovative combination technology has the potential to overcome the translational barriers related to alginate hydrogel delivery to the myocardium.

引用

页码：842 / 850

页数：9

共 42 条

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