A Phase 1 Single Ascending Dose Study of the Novel GLP-1R Agonist GL0034 in Subjects With Obesity

被引:0
|
作者
Thennati, Rajamannar
Burade, Vinod
Natarajan, Muthukumar
Shahi, Pradeep
Nagaraja, Ravishankara
Panchal, Satish
Agrawal, Sudeep
Jandrain, Bernard
Duvauchelle, Thierry
Pratley, Richard
Thorens, Bernard
Vilsboll, Tina
机构
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
577
引用
收藏
页码:284 / 284
页数:1
相关论文
共 50 条
  • [1] A single ascending dose study of the novel GLP-1 receptor agonist GL0034 (utreglutide) in individuals with obesity without diabetes
    Thennati, R.
    Burade, V.
    Natarajan, M.
    Shahi, P.
    Nagaraja, R.
    Panchal, S.
    Agrawal, S.
    Jandrain, B.
    Duvauchelle, T.
    Garcia-Ocana, A.
    Rutter, G. A.
    Pratley, R. E.
    Thorens, B.
    Vilsboll, T.
    DIABETOLOGIA, 2023, 66 (SUPPL 1) : S320 - S321
  • [2] A Single Ascending Dose Study of the Novel GLP-1 Receptor Agonist GL0034 (Utreglutide) in Obese Individuals without Diabetes
    Thennati, Rajamannar
    Burade, Vinod S.
    Natarajan, Muthukumaran
    Shahi, Pradeep
    Nagaraja, Ravishankara
    Panchal, Satish T.
    Agrawal, Sudeep K.
    Jandrain, Bernard
    Duvauchelle, Thierry
    Garcia-Ocana, Adolfo
    Rutter, Guy A.
    Pratley, Richard E.
    Thorens, Bernard
    Vilsboll, Tina
    DIABETES, 2023, 72
  • [3] Binding Kinetics, GLP-1 Receptor Internalization, and Effects on Insulin Secretion for GL0034 and Related GLP-1R Agonists
    Carrat, Gaelle
    Nguyen-Tu, Marie-Sophie
    Leclerc, Isabelle
    Thennati, Rajamannar
    Jones, Ben
    Tomas, Alejandra
    Rutter, Guy A.
    DIABETES, 2020, 69
  • [4] GL0034 (Utreglutide), a novel, long acting, glucagon-like peptide 1 receptor agonist (GLP-1 RA), results of a phase 1 study in healthy individuals
    Thennati, Rajamannar
    Burade, Vinod
    Natarajan, Muthukumaran
    Shahi, Pradeep
    Nagaraja, Ravishankara
    Panchal, Satish
    Agrawal, Sudeep
    Jandrain, Bernard
    Duvauchelle, Thierry
    Pratley, Richard E.
    Thorens, Bernard
    Vilsboll, Tina
    JOURNAL OF HEPATOLOGY, 2023, 78 : S607 - S608
  • [5] Safety, tolerability and metabolic effects of once weekly GL0034 (Utreglutide) in individuals with obesity: a multiple ascending dose study
    Thennati, R.
    Burade, V.
    Nagarajan, M.
    Shahi, P.
    Nagaraja, R.
    Agrawal, S.
    Duvauchelle, T.
    Garcia-Ocana, A.
    Rutter, G.
    Pratley, R. E.
    Thorens, B.
    Vilsboll, T.
    DIABETOLOGIA, 2024, 67 : S359 - S360
  • [6] The GLP-1 receptor agonist GL0034 activates central regions controlling glucose homeostasis and feeding behaviour
    Picard, A.
    Tarussio, D.
    Thennati, R.
    Burade, V.
    Thorens, B.
    DIABETOLOGIA, 2020, 63 (SUPPL 1) : S278 - S279
  • [7] The Effect of Bispecific GLP-1R/GLP-2R Agonist Compared with Dual GLP-1R/GLP-2R Agonist and Dual GLP-1R/GIPR Agonist in Diet-Induced Obesity Mouse Model
    Oh, Timothy
    Yang, Sang-In
    Roh, Jaeil
    Sung, Jee Yoon
    DIABETES, 2023, 72
  • [8] The GLP-1 Receptor Agonist GL0034 Activates Central Regions Controlling Glucose Homeostasis and Feeding Behavior
    Picard, Alexandre
    Tarussio, David
    Thennati, Rajamannar
    Burade, Vinod S.
    Thorens, Bernard
    DIABETES, 2020, 69
  • [9] GL0034 (Utreglutide), a long acting, glucagon-like peptide-1 receptor agonist, improves body weight loss, lipid and liver injury markers in individuals with obesity: A phase 1 multiple ascending dose study
    Thennati, Rajamannar
    Burade, Vinod
    Natarajan, Muthukumaran
    Shahi, Pradeep
    Nagaraja, Ravishankara
    Agrawal, Sudeep
    Jandrain, Bernard
    Duvauchelle, Thierry
    Pratley, Richard E.
    Thorens, Bernard
    Vilsboll, Tina
    Loomba, Rohit
    JOURNAL OF HEPATOLOGY, 2024, 80 : S615 - S616
  • [10] Safety, Tolerability, and Metabolic Effects of Once-Weekly GL0034 (Utreglutide) in Individuals with Obesity-A Multiple Ascending Dose Study
    Thennati, Rajamannar
    Burade, Vinod S.
    Natarajan, Muthukumaran
    Shahi, Pradeep
    Nagaraja, Ravishankara
    Agrawal, Sudeep K.
    Duvauchelle, Thierry
    Garcia-Ocana, Adolfo
    Rutter, Guy A.
    Pratley, Richard E.
    Thorens, Bernard
    Vilsboll, Tina
    DIABETES, 2024, 73