Environmentally benign synthesis of 2,4-diarylquinolines under metal- & solvent-free conditions

被引：5
|
作者：
Faraz, Simra [1 ]
Yashmin, Sabina [1 ]
Marathe, Mayura Dilip [1 ]
Khan, Abu Taleb [1 ]
机构：
[1] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, India
来源：
TETRAHEDRON LETTERS | 2023年 / 120卷
关键词：
P-TSA; H2O; Solvent-free conditions; The three-component reaction; 2; 4-Diarylquinoline; p-Anisidine; MEDIATED SYNTHESIS; QUINOLINE; DERIVATIVES; ALKYNES; ANALOGS;
D O I：
10.1016/j.tetlet.2023.154433
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of 2,4-diarylquinolines is reported by employing arylamine, aryl aldehyde, and aryl acety-lene using 30 mol% p-toluenesulfonic acid monohydrate (p-TSA center dot H2O) as a catalyst at 110 degrees C temperature under solvent-free conditions via a one-pot three-component reaction. The salient features of the present protocol are the nonrequirement of a metal catalyst, additive, solvent, and inert atmospheric reaction conditions, good yield, substrate scope, and shorter reaction time. Using 30 mol% p-toluenesulfonic acid monohydrate (p-TSA center dot H2O) as a catalyst in solvent-free conditions has made the three-component reac-tion efficient enough to form 2,4-diarylquinoline without the involvement of any heavy metal catalyst or additives.(c) 2023 Elsevier Ltd. All rights reserved.
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页数：5
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