Rapidly Disseminated Kaposi's Sarcoma Despite Initiation of Antiretroviral Therapy

Kaposi's sarcoma (KS) is the most common malignancy in people living with HIV. The reported incidence of AIDS -related KS has been dramatically decreased with the introduction of antiretroviral therapy (ART). Systemic treatment with ART is indicated for patients with AIDS -related KS; however, some patients may develop KS -related immune reconstitution inflammatory syndrome characterized by sudden rapid progression of new or pre-existing KS within the initiation of ART. Here, we present a case of rapidly disseminated KS with widespread visceral involvement despite ART initiation in a 27 -year -old African American man with advanced HIV/AIDS.