Augmented wound healing potential of photosensitive GelMA hydrogel incorporating antimicrobial peptides and MXene nanoparticles

被引:4
|
作者
Liang, Chengzhi [1 ,2 ]
Wang, Hongyu [1 ]
Lin, Zhihao [1 ]
Zhang, Chengdong [1 ]
Liu, Guoming [1 ]
Hu, Yanling [1 ]
机构
[1] Qingdao Univ, Dept Orthopaed Surg, Affiliated Hosp, Qingdao, Shandong, Peoples R China
[2] Nanchang Univ, Affiliated Hosp 2, Dept Orthopaed Surg, Nanchang, Jiangxi, Peoples R China
基金
中国国家自然科学基金;
关键词
composite hydrogel; antimicrobial peptides; MXene nanoparticles; wound dressing; GelMA; IN-VITRO; ANGIOGENESIS;
D O I
10.3389/fbioe.2023.1310349
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Introduction: Wound healing is a delicate and complex process influenced by many factors. The treatment of skin wounds commonly involves the use of wound dressings, which remain a routine approach. An ideal dressing can provide protection and a suitable environment for wound surfaces by maintaining moisture and exhibiting good biocompatibility, mechanical strength, and antibacterial properties to promote healing and prevent infection.Methods: We encapsulated tick-derived antibacterial polypeptides (Os) as a model drug within a methylacrylyl gelatin (GelMA) hydrogel containing MXene nanoparticles. The prepared composite hydrogels were evaluated for their wound dressing potential by analyzing surface morphology, mechanical properties, swelling behavior, degradation properties, antibacterial activity, and cytocompatibility.Results: The results demonstrated excellent mechanical strength, swelling performance, degradation behavior, and antibacterial activity of the prepared composite hydrogels, effectively promoting cell growth, adhesion, and expression of antibacterial peptide activity. A full-thickness rat wound model then observed the wound healing process and surface interactions between the composite hydrogels and wounds. The composite hydrogel significantly accelerated wound closure, reduced inflammation, and sped epithelial formation and maturation.Discussion: Incorporating antibacterial peptides into GelMA provides a feasible strategy for developing excellent antibacterial wound dressings capable of tissue repair. In conclusion, this study presents a GelMA-based approach for designing antibacterial dressings with strong tissue regenerative ability.
引用
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页数:13
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