Prevalence and factors associated with the occurrence of pathological fractures and their impact on the overall survival of patients with bone metastases under palliative care

被引:1
|
作者
de Resende, Juliana Miranda Dutra [1 ,3 ]
de Olivera, Livia Costa [1 ]
de Aguiar, Suzana Sales [2 ]
Silva, Francine Peres [1 ]
Muniz, Andrezza Helena Regadas [1 ]
Bergmann, Anke [2 ]
机构
[1] Brazilian Natl Canc Inst, Palliat Care Unit, Rio De Janeiro, Brazil
[2] Brazilian Natl Canc Inst, Clin Res Coordinat, Rio De Janeiro, Brazil
[3] Inst Nacl Canc, Rua Visconde St Isabel 274 HCIV, Rio De Janeiro, Brazil
关键词
rehabilitation; advance care planning; bone; supportive care; SKELETAL-RELATED EVENTS; CANCER-PATIENTS; BREAST;
D O I
10.1136/spcare-2023-004582
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Objectives To assess the prevalence and factors associated with the occurrence of pathological fractures and their impact on the overall survival of patients with bone metastases under palliative care.Methods An observational retrospective cohort assessment concerning both male and female patients with cancer presenting with bone metastases referred to a palliative care unit. Sociodemographic and clinical data were obtained before and after care unit referral. Patients were followed up until death or the last follow-up (4 years after referral). Logistic regression models and survival curves employing a log-rank test were applied.Results A total of 348 patients were included in the study. Most were <65 years (65%) and female (62%), and the most frequent primary tumour site was the breast (40%). The prevalence of pathological fractures was 28%, more frequent in the axial skeleton (49%), with no association with overall patient survival (p=0.348). Patients with breast cancer exhibited a 2.96-fold higher chance (95% CI: 1.80 to 4.86) of developing a fracture compared with other tumours, and not receiving previous radiotherapy increased the chances of fracture occurrence by 5.60-fold (95% CI: 2.46 to 12.77).Conclusion A high prevalence of pathological fractures was observed. Presenting with breast cancer and not having undergone previous radiotherapy increase the chances of fracture occurrence, although this is not associated with overall survival in patients under palliative care.
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页数:8
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