Fragile-like regulatory T cells modulate opioid withdrawal in humans and mice

被引：2

作者：

Mikati, Marwa O. ^{[1
,2
,3
]}

Klein, Robyn S. ^{[1
,4
,5
]}

机构：

[1] Ctr Neuroimmunol & Neuroinfect Dis, St Louis, MO 63110 USA

[2] Univ Hlth Sci & Pharm, Ctr Clin Pharmacol, St Louis, MO USA

[3] Washington Univ, Sch Med, Dept Anesthesiol, St Louis, MO USA

[4] Washington Univ, Dept Med, Sch Med, St Louis, MO 63110 USA

[5] Washington Univ, Sch Med, Dept Immunol & Neurosci, St Louis, MO 63110 USA

来源：

IMMUNITY | 2023年 / 56卷 / 02期

关键词：

D O I：

10.1016/j.immuni.2023.01.021

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Opioid use alters peripheral immune functions via unknown mechanisms. In a recent issue of Cell, Zhu et al. report increased fragile-like regulatory T cells in patients with opioid use disorder and in morphine-treated mice. In mice, Treg cell-derived interferon-g within the brain promotes withdrawal-associated alterations in synapses.

引用

页码：237 / 239

页数：3

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