Metabolomics in pediatric lower respiratory tract infections and sepsis: a literature review

被引：3
|
作者：
Wildman, Emily [1 ]
Mickiewicz, Beata [2 ]
Vogel, Hans J. [3 ]
Thompson, Graham C. [2 ,4 ]
机构：
[1] Univ Calgary, Cumming Sch Med, Calgary, AB, Canada
[2] Univ Calgary, Cumming Sch Med, Dept Pediat, Calgary, AB, Canada
[3] Univ Calgary, BioNMR Ctr, Dept Biol Sci, Calgary, AB, Canada
[4] Univ Calgary, Cumming Sch Med, Dept Emergency Med, Calgary, AB, Canada
来源：
PEDIATRIC RESEARCH | 2023年 / 93卷 / 03期
关键词：
SEPTIC SHOCK; STREPTOCOCCUS-PNEUMONIAE; SYNCYTIAL VIRUS; BRONCHIOLITIS; BIOMARKERS; SEVERITY; ASTHMA; TRENDS; EPIDEMIOLOGY; CHILDREN;
D O I：
10.1038/s41390-022-02162-0
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Lower respiratory tract infections (LRTIs) are a leading cause of morbidity and mortality in children. The ability of healthcare providers to diagnose and prognose LRTIs in the pediatric population remains a challenge, as children can present with similar clinical features regardless of the underlying pathogen or ultimate severity. Metabolomics, the large-scale analysis of metabolites and metabolic pathways offers new tools and insights that may aid in diagnosing and predicting the outcomes of LRTIs in children. This review highlights the latest literature on the clinical utility of metabolomics in providing care for children with bronchiolitis, pneumonia, COVID-19, and sepsis. Impact This article summarizes current metabolomics approaches to diagnosing and predicting the course of pediatric lower respiratory infections. This article highlights the limitations to current metabolomics research and highlights future directions for the field.
引用
收藏
页码：492 / 502
页数：11
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