Efficient Synthesis of the Key Intermediate of Scopolamine by [4+3] Cycloaddition Reaction

被引：0

作者：

Duan, Xiuyuan ^{[1
]}

Wang, Qian ^{[1
]}

Shahab, Muhammad ^{[1
]}

Liang, Chaoqun ^{[1
]}

Li, Gudong ^{[1
]}

Zheng, Guojun ^{[1
]}

机构：

[1] Beijing Univ Chem Technol, State Key Lab Chem Resources Engn, Beijing 100029, Peoples R China

来源：

LETTERS IN ORGANIC CHEMISTRY | 2023年 / 20卷 / 02期

基金：

国家重点研发计划; 北京市自然科学基金;

关键词：

Scopolamine; 6,7-dehydrotropinone; 4+3] Cycloaddition reaction; Barton-McCombie deoxygenation; mild reaction conditions; better application perspective; DEOXYGENATION;

D O I：

10.2174/1570178619666220902145750

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Scopolamine, as an anticholinergic agent, plays a regulatory role in the peripheral nervous system. In this paper, 6,7-dehydrotropinone, which is the key intermediate of scopolamine, is synthesized in moderate yield through [4+3] cyclization reaction and Barton deoxygenation reaction. This route has good application prospects with mild reaction conditions, moderate yield, and simple operating procedures.

引用

页码：117 / 122

页数：6

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