Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults

被引：0

作者：

Su, Jinni ^{[1
]}

Kuo, Sally I-Chun ^{[2
]}

Aliev, Fazil ^{[2
]}

Rabinowitz, Jill A. ^{[3
]}

Jamil, Belal ^{[1
]}

Chan, Grace ^{[4
,5
]}

Edenberg, Howard J. ^{[6
]}

Francis, Meredith ^{[7
]}

Hesselbrock, Victor ^{[4
]}

Kamarajan, Chella ^{[8
]}

Kinreich, Sivan ^{[8
]}

Kramer, John ^{[5
]}

Lai, Donbing ^{[6
]}

Mccutcheon, Vivia ^{[7
]}

Meyers, Jacquelyn ^{[8
]}

Pandey, Ashwini ^{[8
]}

Pandey, Gayathri ^{[8
]}

Plawecki, Martin H. ^{[9
]}

Schuckit, Marc ^{[10
]}

Tischfield, Jay ^{[11
]}

Dick, Danielle M. ^{[12
]}

机构：

[1] Arizona State Univ, Dept Psychol, Tempe, AZ 85281 USA

[2] Rutgers State Univ, Dept Psychiat, New Brunswick, NJ USA

[3] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA

[4] Univ Connecticut, Dept Psychiat, Farmington, CT USA

[5] Univ Iowa, Dept Psychiat, Iowa City, IA USA

[6] Indiana Univ, Dept Biochem & Mol Biol, Indianapolis, IN USA

[7] Washington Univ, Dept Psychiat, St Louis, MO USA

[8] SUNY Downstate Med Ctr, Dept Psychiat, Brooklyn, NY USA

[9] Indiana Univ, Dept Psychiat, Bloomington, IN USA

[10] Univ Calif San Diego, Dept Psychiat, La Jolla, CA USA

[11] Rutgers State Univ, Dept Genet, New Brunswick, NJ USA

[12] Rutgers State Univ, Rutgers Addict Res Ctr, New Brunswick, NJ USA

来源：

DEVELOPMENT AND PSYCHOPATHOLOGY | 2023年

关键词：

polygenic scores; gene-environment interaction; social support; alcohol use; COGA; ENVIRONMENT INTERACTION RESEARCH; EARLY ADOLESCENCE; FINANCIAL STRESS; USE DISORDERS; DRINKING; FAMILY; ASSOCIATIONS; 5-HTTLPR; HEALTH; CHALLENGES;

D O I：

10.1017/S0954579423001141

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Alcohol use is influenced by genetic and environmental factors. We examined the interactive effects between genome-wide polygenic risk scores for alcohol use (alc-PRS) and social support in relation to alcohol use among European American (EA) and African American (AA) adults across sex and developmental stages (emerging adulthood, young adulthood, and middle adulthood). Data were drawn from 4,011 EA and 1,274 AA adults from the Collaborative Study on the Genetics of Alcoholism who were between ages 18-65 and had ever used alcohol. Participants completed the Semi-Structured Assessment for the Genetics of Alcoholism and provided saliva or blood samples for genotyping. Results indicated that social support from friends, but not family, moderated the association between alc-PRS and alcohol use among EAs and AAs (only in middle adulthood for AAs); alc-PRS was associated with higher levels of alcohol use when friend support was low, but not when friend support was high. Associations were similar across sex but differed across developmental stages. Findings support the important role of social support from friends in buffering genetic risk for alcohol use among EA and AA adults and highlight the need to consider developmental changes in the role of social support in relation to alcohol use.

引用

页数：13

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