Quantitative Immunofluorescence Evaluation of PD-L1 Expression in Non-Muscle-Invasive and Muscle-Invasive Urothelial Bladder Cancer

被引：0

作者：

Bogush, T. A. ^{[1
]}

Spiridonova, K. S. ^{[1
,2
]}

Bogush, E. A. ^{[3
]}

Grishanina, A. N. ^{[1
]}

Scherbakov, A. M. ^{[1
]}

Volkova, M. I. ^{[4
]}

Safarov, Z. M. ^{[1
]}

Matveev, V. B. ^{[1
]}

Kosorukov, V. S. ^{[1
]}

机构：

[1] Minist Hlth Russian Federat, Blokhin Natl Med Res Ctr Oncol, Moscow 115478, Russia

[2] Moscow MV Lomonosov State Univ, Dept Fundamental Med, Moscow 119991, Russia

[3] Sechenov First Moscow State Med Univ, Moscow 119991, Russia

[4] Russian Med Acad Continuous Profess Educ, Moscow 125445, Russia

来源：

MOSCOW UNIVERSITY CHEMISTRY BULLETIN | 2023年 / 78卷 / 06期

关键词：

muscle-invasive and non-muscle-invasive bladder cancer; PD-L1; immunofluorescence analysis; flow cytometry;

D O I：

10.3103/S0027131423060032

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The expression of PD-L1 protein is quantified in 56 samples of urothelial bladder cancer (BC). PD-L1 expression is detected in all BC samples, while in non-muscle-invasive bladder cancer (NMIBC) this score is 1.5 times higher than in muscle-invasive bladder cancer (MIBC) (p = 0.001). High PD-L1 expression level (>= 30%) is observed in 20% of MIBC samples and among NMIBC tumors in 68% of cases, i.e., 3.4 times more often (p = 0.0004). The last fact justifies the prospect of starting therapy with immune checkpoint inhibitors at the onset of the disease for NMIBC.

引用

页码：338 / 343

页数：6

共 50 条

[1] Quantitative Immunofluorescence Evaluation of PD-L1 Expression in Non-Muscle-Invasive and Muscle-Invasive Urothelial Bladder Cancer
T. A. Bogush
K. S. Spiridonova
E. A. Bogush
A. N. Grishanina
A. M. Scherbakov
M. I. Volkova
Z. M. Safarov
V. B. Matveev
V. S. Kosorukov
[J]. Moscow University Chemistry Bulletin, 2023, 78 : 338 - 343
[2] Dynamic expression changes between non-muscle-invasive bladder cancer and muscle-invasive bladder cancer
Zhao, Yu-gang
Shi, Bing-yi
Qian, Ye-yong
Bai, Hong-wei
Xiao, Li
He, Xiu-yun
[J]. TUMORI JOURNAL, 2014, 100 (06): : E273 - E281
[3] Predictors of Outcome of Non-Muscle-Invasive and Muscle-Invasive Bladder Cancer
Youssef, Ramy F.
Lotan, Yair
[J]. THESCIENTIFICWORLDJOURNAL, 2011, 11 : 369 - 381
[4] Does PD-L1 Expression in Non-Muscle-Invasive Bladder Cancer Correlate with Recurrence and Progression?
Gajzer, David
Becerra, Maria
Escobar, Maria Velasquez
Kwon, Deukwoo
Ritch, Chad
Kryvenko, Oleksandr
Jorda, Merce
[J]. MODERN PATHOLOGY, 2019, 32
[5] Does PD-L1 Expression in Non-Muscle-Invasive Bladder Cancer Correlate with Recurrence and Progression?
Gajzer, David
Becerra, Maria
Escobar, Maria Velasquez
Kwon, Deukwoo
Ritch, Chad
Kryvenko, Oleksandr
Jorda, Merce
[J]. LABORATORY INVESTIGATION, 2019, 99
[6] Updates for the radiologist in non-muscle-invasive, muscle-invasive, and metastatic bladder cancer
Jooae Choe
Marta Braschi-Amirfarzan
Sree Harsha Tirumani
Atul B. Shinagare
Kyung Won Kim
Nikhil H. Ramaiya
Katherine M. Krajewski
[J]. Abdominal Radiology, 2017, 42 : 2710 - 2724
[7] Updates for the radiologist in non-muscle-invasive, muscle-invasive, and metastatic bladder cancer
Choe, Jooae
Braschi-Amirfarzan, Marta
Tirumani, Sree Harsha
Shinagare, Atul B.
Kim, Kyung Won
Ramaiya, Nikhil H.
Krajewski, Katherine M.
[J]. ABDOMINAL RADIOLOGY, 2017, 42 (11) : 2710 - 2724
[8] Collagen stiffness promoted non-muscle-invasive bladder cancer progression to muscle-invasive bladder cancer
Zhu, Huier
Chen, Hui
Wang, Jizhong
Zhou, Ling
Liu, Shaoyan
[J]. ONCOTARGETS AND THERAPY, 2019, 12 : 3441 - 3457
[9] PD-L1 EXPRESSION AND BCG RESPONSE IN NON-MUSCLE INVASIVE BLADDER CANCER
Woldu, Solomon
Gerald, Thomas
Margulis, Vitaly
Halstuch, Daniel
Ber, Yaara
Lifshitz, Karin
Margel, David
Tikva, Petah
Lotan, Yair
Jia, Liwei
[J]. JOURNAL OF UROLOGY, 2022, 207 (05): : E1003 - E1003
[10] Expression of PD-L1 and BCG immunotherapy in non-muscle invasive bladder cancer
Heo, Jun Hyeok
Jin, Hyun A.
Kang, You Hyun
Kim, Ki Hong
Hong, Sung Joon
Han, Kyung Seok
[J]. CANCER RESEARCH, 2016, 76

← 1 2 3 4 5 →