m-Cresol,a pesticide intermediate, induces hepatotoxicity and behavioral abnormalities in zebrafish larvae through oxidative stress, apoptosis

被引：3
|
作者：
Wang, Ying [1 ,3 ]
Wu, Jie [3 ]
Wan, Mengqi [2 ]
Yang, Dou [1 ]
Liu, Fasheng [3 ]
Li, Kehao [2 ]
Hu, Manxin [2 ]
Tang, Yuanyuan [1 ]
Lu, Huiqiang [3 ,4 ]
Zhang, Shouhua [2 ,5 ]
Xiong, Yuanzhen [1 ]
机构：
[1] Nanchang Univ, Coll Informat Engn, Nanchang 330027, Jiangxi, Peoples R China
[2] Affiliated Childrens Hosp, Dept Gen Surg, Nanchang Med Coll, Nanchang 330006, Peoples R China
[3] Jinggangshan Univ, Coll Life Sci, Jiangxi Engn Lab Zebrafish Modeling & Drug Screen, Jiangxi Key Lab Dev Biol Organs, Jian 343009, Jiangxi, Peoples R China
[4] Jinggangshan Univ, Affiliated Hosp, Jian 343000, Jiangxi, Peoples R China
[5] Nanchang Univ, Dept Gen Surg, Affiliated Childrens Hosp, 122 Yangming Rd, Nanchang 330006, Jiangxi, Peoples R China
来源：
TOXICOLOGY IN VITRO | 2024年 / 94卷
基金：
中国国家自然科学基金;
关键词：
m-cresol; zebrafish larvae; hepatotoxicity; CRESOL;
D O I：
10.1016/j.tiv.2023.105723
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
m-Cresol is mainly used as a pesticide intermediate. It is industrially used in the production of insecticides including boronone and fenthion. It is also an intermediate for color film, resins, plasticizers and fragrances. However, m-cresol has the potential to cause environmental contamination if released accidentally. The molecular mechanism of m-cresol mediated hepatotoxicity remains unclear. In this study, zebrafish larvae were used to comprehensively study the hepatotoxicity of m-cresol and explore its molecular mechanism. After 72 hpf of fertilization, zebrafish larvae were exposed to 0.2 mM,0.4 mM, and 0.6 mM of m-cresol. Varying degrees of liver injury and behavioral abnormalities were observed. The hepatotoxicity of zebrafish larvae may be induced by oxidative stress pathway and apoptosis of cell.
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页数：9
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