Partially hydrolyzed guar gum suppresses the progression of pulmonary arterial hypertension in a SU5416/hypoxia rat model

被引：2
|
作者：
Sanada, Takayuki J. [1 ,2 ,3 ,13 ,14 ]
Hosomi, Koji [1 ,2 ]
Park, Jonguk [4 ]
Naito, Akira [3 ]
Sakao, Seiichiro [3 ]
Tanabe, Nobuhiro [3 ,5 ]
Kunisawa, Jun [1 ,2 ,4 ,6 ,7 ,8 ,9 ,10 ,11 ,12 ]
Tatsumi, Koichiro [3 ]
Suzuki, Takuji [3 ]
机构：
[1] Natl Inst Biomed Innovat Hlth & Nutr NIBIOHN, Microbial Res Ctr Hlth & Med, Lab Vaccine Mat, Osaka, Japan
[2] Natl Inst Biomed Innovat Hlth & Nutr NIBIOHN, Microbial Res Ctr Hlth & Med, Lab Gut Environm Syst, Osaka, Japan
[3] Chiba Univ, Grad Sch Med, Dept Respirol, Chiba, Japan
[4] Natl Inst Biomed Innovat Hlth & Nutr NIBIOHN, Artificial Intelligence Ctr Hlth & Biomed Res, Osaka, Japan
[5] Chibaken Saiseikai Narashino Hosp, Dept Respirol, Narashino, Japan
[6] Osaka Univ, Grad Sch Pharmaceut Sci, Osaka, Japan
[7] Osaka Univ, Grad Sch Med, Osaka, Japan
[8] Osaka Univ, Grad Sch Dent, Osaka, Japan
[9] Osaka Univ, Grad Sch Sci, Osaka, Japan
[10] Kobe Univ, Grad Sch Med, Dept Microbiol & Immunol, Kobe, Hyogo, Japan
[11] Univ Tokyo, Inst Med Sci, Int Vaccine Design Ctr, Tokyo, Japan
[12] Waseda Univ, Res Org Nano & Life Innovat, Tokyo, Japan
[13] Natl Inst Biomed Innovat Hlth & Nutr NIBIOHN, Microbial Res Ctr Hlth & Med, Lab Vaccine Mat, 7-6-8 Saito Asagi, Osaka, Ibaraki 5670085, Japan
[14] Natl Inst Biomed Innovat Hlth & Nutr NIBIOHN, Microbial Res Ctr Hlth & Med, Lab Gut Environm Syst, 7-6-8 Saito Asagi, Osaka, Ibaraki 5670085, Japan
来源：
PULMONARY CIRCULATION | 2023年 / 13卷 / 03期
基金：
日本学术振兴会;
关键词：
Akkermansia; bacteroidetes S27-7; dietary fiber; gut dysbiosis; prebiotics;
D O I：
10.1002/pul2.12266
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This study investigated the effects of partially hydrolyzed guar gum (PHGG) on the development of pulmonary arterial hypertension using a SU5416/hypoxia rat model. Our results demonstrated that PHGG treatment suppressed the development of pulmonary hypertension and vascular remodeling with an altered gut microbiota composition.
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页数：6
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