Low-dose belantamab mafodotin (belamaf) in combination with nirogacestat vs belamaf monotherapy in patients with relapsed/refractory multiple myeloma (RRMM): phase I/II DREAMM-5 platform sub-study 3

被引:0
|
作者
Leypoldt, L. [1 ]
Callander, N. S. [2 ]
Richardson, P. G. [3 ]
Hus, M. [4 ]
Ribrag, V. [5 ]
Lopez, J. M. [6 ]
Kim, K. [7 ]
Lee, J. H. [8 ]
Dimopoulos, M. A. [9 ,10 ]
Schjesvold, F. [11 ,12 ]
Facon, T. [13 ]
Jo, J. -C. [14 ]
Min, C. -K. [15 ]
Mielnik, M. [4 ]
Cheng, S. [16 ]
Smith, L. M. [16 ]
Breitbach, C. J. [16 ]
Brawley, C. [17 ]
Sembhi, H. [17 ]
LaMacchia, J. [18 ]
Grosicki, S. [19 ]
机构
[1] Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany
[2] Univ Wisconsin, Carbone Canc Ctr, Madison, WI USA
[3] Dana Farber Canc Inst, Boston, MA 02115 USA
[4] Katedra & Klin Hematoonkol & Transplantacji Szpik, Lublin, Poland
[5] Inst Gustave Roussy, Villejuif, France
[6] Univ Complutense Madrid, Hosp Univ 12 Octubre, Dept Hematol, CNIO,CIBERONC, Madrid, Spain
[7] Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Seoul, South Korea
[8] Gachon Univ, Gachon Univ Gil Med Ctr, Coll Med, Incheon, South Korea
[9] Natl & Kapodistrian Univ Athens, Sch Med, Athens, Greece
[10] Alexandra Hosp, Athens, Greece
[11] Oslo Univ Hosp, Oslo Myeloma Ctr, Dept Hematol, Oslo, Norway
[12] Univ Oslo, KG Jebsen Ctr B Cell Malignancies, Oslo, Norway
[13] Lille Univ Hosp, Dept Haematol, Lille, France
[14] Univ Ulsan, Ulsan Univ Hosp, Coll Med, Ulsan, South Korea
[15] Catholic Univ Korea, Seoul St Marys Hosp, Seoul, South Korea
[16] SpringWorks Therapeut, Stamford, CT USA
[17] GSK, Stevenage, Herts, England
[18] GSK, Waltham, MA USA
[19] Med Univ Silesia, Dept Hematol & Canc Prevent, Katowice, Poland
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
P330
引用
收藏
页码:176 / 177
页数:2
相关论文
共 50 条
  • [1] Low-Dose Belantamab Mafodotin (Belamaf) in Combination With Nirogacestat Versus Belamaf Monotherapy in Patients With Relapsed/Refractory Multiple Myeloma (RRMM): Phase 1/2 DREAMM-5 Platform Sub-Study 3
    Callander, Natalie S.
    Richardson, Paul G.
    Hus, Marek
    Ribrag, Vincent
    Lopez, Joaquin Martinez
    Kim, Kihyun
    Lee, Jae Hoon
    Dimopoulos, Meletis
    Schjesvold, Fredrik
    Facon, Thierry
    Jo, Jae-Cheol
    Min, Chang-Ki
    Mielnik, Michal
    Cheng, Shinta
    Smith, L. Mary
    Breitbach, Caroline J.
    Brawley, Chris
    Sembhi, Harjeet
    LaMacchia, John
    Hakim, Shawn
    Kremer, Brandon E.
    Grosicki, Sebastian
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2023, 23 : S507 - S508
  • [2] Dreamm-5 Platform Trial: Belantamab Mafodotin (Belamaf) in Combination with Four Different Novel Agents in Patients with Relapsed/Refractory Multiple Myeloma (RRMM)
    Richardson, Paul G.
    Nooka, Ajay
    Quach, Hang
    Trudel, Suzanne
    Routledge, David
    Song, Kevin
    Nahi, Hareth
    Paul, Sofia
    Khan, Josephine
    Brouch, Maria
    Ferron-Brady, Geraldine
    Yeakey, Anne
    Shelton, Chris
    de Oca, Rocio Montes
    Smith, L. Mary
    Im, Ellie
    Ahlers, Christoph M.
    Paul, Elaine M.
    Holkova, Beata
    Gupta, Ira
    Kremer, Brandon E.
    Rodriguez-Otero, Paula
    BLOOD, 2020, 136
  • [3] DREAMM-5 platform trial: Belantamab mafodotin (belamaf; GSK2857916) in combination with five different novel agents in patients with relapsed/refractory multiple myeloma (RRMM)
    Richardson, Paul G.
    Trudel, Suzanne
    Callander, Natalie S.
    Nooka, Ajay
    Song, Kevin
    Uttervall, Katarina
    Minnema, Monique C.
    Rodriguez-Otero, Paula
    Struemper, Herbert
    Yeakey, Anne
    de Oca, Rocio Montes
    Smith, L. Mary
    Jackson, Nicola
    Kaisermann, Morrys
    Im, Ellie
    Basile, Frank G.
    Ahlers, Christoph M.
    Holkova, Beata
    Gupta, Ira
    Kremer, Brandon E.
    Quach, Hang
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2021, 21 : S156 - S156
  • [4] Synergistic effects of low-dose belantamab mafodotin in combination with a gamma-secretase inhibitor (nirogacestat) in patients with relapsed/refractory multiple myeloma (RRMM): DREAMM-5 study.
    Lonial, Sagar
    Grosicki, Sebastian
    Hus, Marek
    Song, Kevin W.
    Facon, Thierry
    Callander, Natalie Scott
    Ribrag, Vincent
    Uttervall, Katarina
    Quach, Hang
    Vorobyev, Vladimir I.
    Min, Chang Ki
    Cheng, Shinta
    Smith, L. Mary
    Yu, Jing
    Collingwood, Therese
    Holkova, Beata
    Kremer, Brandon
    Gupta, Ira
    Richardson, Paul G.
    Minnema, Monique C.
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (16)
  • [5] DREAMM-5 platform trial: Belantamab Mafodotin (GSK2857916; belamaf; BLENREP) in combination with five different novel agents in patients (Pts) with Relapsed/Refractory Multiple Myeloma (RRMM)
    Weisel, K.
    Richardson, P. G.
    Trudel, S.
    Callander, N.
    Nooka, A.
    Song, K.
    Uttervall, K.
    Minnema, M. C.
    Rodriguez-Otero, P.
    Struemper, H.
    Yeakey, A.
    de Oca, Montes R.
    Smith, L. M.
    Jackson, N.
    Kaisermann, M.
    Im, E.
    Basile, F. G.
    Ahlers, C. M.
    Holkova, B.
    Gupta, I
    Kremer, B. E.
    Quach, H.
    ONCOLOGY RESEARCH AND TREATMENT, 2021, 44 : 204 - 205
  • [6] DREAMM-5 platform trial: Belantamab mafodotin in combination with novel agents in patients with relapsed/refractory multiple myeloma (RRMM).
    Richardson, Paul G.
    Biswas, Swethajit
    Holkova, Beata
    Jackson, Nicola
    Netherway, Thelma
    Paul, Sofia
    Ferron-Brady, Geraldine
    Yeakey, Anne
    Shelton, Chris
    de Oca, Rocio Montes
    Ahlers, Christoph Matthias
    Ballas, Marc S.
    Paul, Elaine Marie
    Gupta, Ira
    Opalinska, Joanna
    Luptakova, Katarina
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (15)
  • [7] DREAMM-6: Safety, Tolerability and Clinical Activity of Belantamab Mafodotin (Belamaf) in Combination with Bortezomib/Dexamethasone (BorDex) in Relapsed/Refractory Multiple Myeloma (RRMM)
    Popat, Rakesh
    Nooka, Ajay
    Stockerl-Goldstein, Keith
    Abonour, Rafat
    Ramaekers, Ryan
    Khot, Amit
    Forbes, Adam
    Lee, Cindy
    Augustson, Bradley
    Spencer, Andrew
    Mateos, Maria-Victoria
    Chopra, Bikramjit
    Rogers, Rachel
    Smith, Deborah A.
    Davidge, Jacqueline
    de Oca, Rocio Montes
    Ferron-Brady, Geraldine
    Yeakey, Anne
    Talekar, Mala
    Kremer, Brandon E.
    Gupta, Ira
    Quach, Hang
    BLOOD, 2020, 136
  • [8] Ocular Health of Patients with Relapsed/Refractory Multiple Myeloma (RRMM): Baseline Data from the DREAMM-2 Trial of Belantamab Mafodotin (Belamaf)
    Popat, Rakesh
    Kazantzi, Aikaterini
    Farooq, Asim
    Thulasi, Praneetha
    Lonial, Sagar
    Jakubowiak, Andrzej
    Badros, Ashraf Z.
    Jeng, Bennie H.
    Opalinska, Joanna
    Baron, January
    Piontek, Trisha
    Byrne, Julie
    Womersley, Lynsey
    Gupta, Ira
    Esposti, Simona Degli
    BLOOD, 2020, 136
  • [9] Patient-Reported Outcomes in Patients With Relapsed or Refractory Multiple Myeloma (RRMM) Treated With Belantamab Mafodotin (Belamaf) Versus Pomalidomide Plus Low-Dose Dexamethasone (Pd) in the DREAMM-3 Study
    Hungria, Vania
    Weisel, Katja
    Currie, Brooke
    Perera, Sue
    Sule, Neal
    He, Wei
    Davy, Katherine
    McKeown, Astrid
    Sapra, Sandhya
    Nelsen, Linda
    Li, Mary
    Barale, Sophie
    Boyle, Julia
    McPoyle, Kaytlyn
    Dimopoulos, Meletios Athanasios
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2023, 23 : S505 - S505
  • [10] Updated Results From DREAMM-3, a Phase 3 Study of Belantamab Mafodotin (Belamaf) Versus Pomalidomide Plus Dexamethasone in Patients (pts) With Relapsed/Refractory Multiple Myeloma (RRMM)
    Hungria, Vania T. M.
    Weisel, Katja
    Radinoff, Atanas
    Delimpasi, Sosana
    Mikala, Gabor
    Masszi, Tamas
    Li, Jian
    Capra, Marcelo
    Maiolino, Angelo
    Pappa, Vasiliki
    Chraniuk, Dominik
    Osipov, Iurii
    Leleu, Xavier
    Low, Michael
    Kouri, Fotini
    Liboon, John
    Brawley, Chris
    Lewis, Eric
    Tubel, Gabriela
    Li, Mary
    McKeown, Astrid
    Roy-Ghanta, Sumita
    Opalinska, Joanna
    Dimopoulos, Meletios
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2024, 24 : S261 - S262