Spatiotemporal dynamics of focal adhesion kinase

被引：1
|
作者：
Li, Xiaoquan [1 ]
Shu, Xiaokun [1 ]
机构：
[1] Univ Calif San Francisco, San Francisco, CA 94143 USA
来源：
NATURE CHEMICAL BIOLOGY | 2023年 / 19卷 / 12期
关键词：
D O I：
10.1038/s41589-023-01371-w
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We designed FAK-SPARK, a fluorescent reporter of focal adhesion kinase (FAK) activity based on phase separation. FAK-SPARK revealed polarized FAK activity within single focal adhesions in the leading edges of migrating cells. By combining FAK-SPARK with DNA tension probes, we showed that FAK activity is proportional to the tension strength.
引用
收藏
页码：1444 / 1445
页数：2
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