A dataset of [ 68 Ga]Ga-Pentixafor PET/CT images of patients with high-grade Glioma

This paper contains single-center prospective informa-tion showing illustrative examples of chemokine receptor -4 (CXCR4) targeting in high-grade glial brain tumors in treatment-naive adult patients using a novel radiolabeled PET tracer: [68Ga]Ga-CXCR4 PET/CT.High-grade glioma is one of the most resistant malignancies to treatment. Despite major breakthroughs in diagnostic and therapeutic approaches, the overall 5-year survival rate re-mains in the 5-10% range. CXCR4 is a chemokine with the C-X-C motif that is overexpressed in high-grade gliomas. The 24 consecutive treatment-naive enrolled patients under-went PET/CT images using the SIEMENS scanner (Biograph6 TrueV) and received the radiotracer intravenously. After ap-proximately 60 min, the PET/CT acquisition was performed with a dedicated scanner and in 10 min time per bed posi-tion. The images were reconstructed and analyzed with the 3D-OSEM algorithm, applying point spread function (PSF) or resolution recovery algorithm (TrueX in Syngo (R) software, Siemens Medical Solution), 3 iterations, and 21 subsets using a 3 mm Gaussian post-smoothing filter.