γδ T cells unveil invisible tumors

被引：1
|
作者：
Koay, Hui-Fern [1 ]
Lynch, Lydia [2 ]
机构：
[1] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Melbourne, Vic, Australia
[2] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA
来源：
TRENDS IN IMMUNOLOGY | 2023年 / 44卷 / 03期
关键词：
D O I：
10.1016/j.it.2023.01.011
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Tumors can evade conventional T cell recognition by rendering the HLA class I antigen presentation system defective. In a recent study, de Vries et al. reveal gamma delta T cells as key contributors to the efficacy of immune checkpoint blockade (ICB) against HLA-I-silenced cancers, highlighting a novel layer of sur-veillance against immune escape by tumors.
引用
收藏
页码：159 / 161
页数：3
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