Coronavirus disease (COVID-19), which emerged in 2019, has induced worldwide chaos. The main cause of COVID-19 mass infection indoors is the spread of virus-containing droplets via indoor airflow, which is affected by air conditioners and purifiers. Here, ten experimental cases were established to analyze how use of air pu-rifiers affects the spread of virus-containing droplets. The experiments were conducted in a school classroom with an air conditioner in summer. In the droplet dispersion experiment, paraffin oil was used as the droplet substance. Two main scenarios were simulated: (1) an infected student was seated in the back of the classroom; and (2) the teacher, standing in the front of the classroom, was infected. The results were expressed using two parameters: peak concentration and loss rate, which reflect the degree of direct and indirect infection (airborne infection), respectively. The air purifier induced a peak concentration decrease of 42% or an increase of 278%, depending on its location in the classroom. Conversely, when the air purifier was operated in the high mode (flow rate = 500 CMH; cubic meters per hour), the loss rate showed that the amount of droplet nuclei only decreased by 39% and the droplet amount decreased by 22%. Thus, the airborne infection degree can be significantly reduced. Finally, the use of air purifiers in the summer may be helpful in preventing group in-fections by reducing the loss rate and peak concentration if the air purifier is placed in a strategic location, according to the airflow of the corresponding room.