Pros and Cons of Cryopreserving Allogeneic Stem Cell Products

被引：0
|
作者：
Valentini, Caterina Giovanna [1 ]
Pellegrino, Claudio [1 ,2 ]
Teofili, Luciana [1 ,2 ]
机构：
[1] Fdn Policlin Univ A Gemelli IRCCS, Dipartimento Diagnost Immagini Radioterapia Oncolo, I-00168 Rome, Italy
[2] Univ Cattolica Sacro Cuore, Dipartimento Sci Radiolog & Ematolog, Sez Ematol, I-00168 Rome, Italy
来源：
CELLS | 2024年 / 13卷 / 06期
关键词：
COVID-19; allogeneic hematopoietic stem cell transplant; cryopreservation; HEMATOPOIETIC PROGENITOR CELLS; MOBILIZED PERIPHERAL-BLOOD; DIMETHYL-SULFOXIDE; T-CELLS; MARROW TRANSPLANTATION; GRAFT CRYOPRESERVATION; INTERNATIONAL BLOOD; MONONUCLEAR-CELLS; UNRELATED DONORS; CD34(+) CELLS;
D O I：
10.3390/cells13060552
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The COVID-19 pandemic has precipitously changed the practice of transplanting fresh allografts. The safety measures adopted during the pandemic prompted the near-universal graft cryopreservation. However, the influence of cryopreserving allogeneic grafts on long-term transplant outcomes has emerged only in the most recent literature. In this review, the basic principles of cell cryopreservation are revised and the effects of cryopreservation on the different graft components are carefully reexamined. Finally, a literature revision on studies comparing transplant outcomes in patients receiving cryopreserved and fresh grafts is illustrated.
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页数：24
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