Allogeneic hematopoietic stem cell transplantation in patients aged 60-79 years in Germany (1998-2018): a registry study

被引：0

作者：

Weller, Jan Frederic ^{[1
]}

Lengerke, Claudia ^{[1
]}

Finke, Juergen ^{[2
]}

Schetelig, Johannes ^{[3
]}

Platzbecker, Uwe ^{[4
]}

Einsele, Hermann ^{[5
]}

Schroeder, Thomas ^{[6
]}

Faul, Christoph ^{[1
]}

Stelljes, Matthias ^{[7
]}

Dreger, Peter ^{[8
]}

Blau, Igor W. ^{[9
]}

Wulf, Gerald ^{[10
]}

Tischer, Johanna ^{[11
]}

Scheid, Christoph ^{[12
,13
]}

Elmaagacli, Ahmet ^{[14
]}

Neidlinger, Helga ^{[15
]}

Flossdorf, Sarah ^{[15
,16
]}

Bornhaeuser, Martin

Bethge, Wolfgang

Fleischhauer, Katharina ^{[15
,17
]}

Kroeger, Nicolaus ^{[15
,18
]}

de Wreede, Liesbeth C. ^{[19
,20
]}

Christopeit, Maximilian ^{[1
]}

机构：

[1] Univ Hosp Tubingen, Dept Internal Med Hematol Oncol Clin Immunol & Rh, Tubingen, Germany

[2] Univ Freiburg, Univ Med Ctr Freiburg, Fac Med, Dept Hematol Oncol & Stem Cell Transplantat, Freiburg, Germany

[3] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Internal Med 1, Dresden, Germany

[4] Leipzig Univ Hosp, Med Clin & Policlin 1, Hematol & Cellular Therapy, Leipzig, Germany

[5] Univ Hosp Wurzburg, Dept Internal Med 2, Wurzburg, Germany

[6] Univ Hosp Essen, West German Canc Ctr Essen, Dept Hematol & Stem Cell Transplantat, Essen, Germany

[7] Univ Hosp Munster, Dept Med A, Munster, Germany

[8] Heidelberg Univ, Dept Orthoped 5, Heidelberg, Germany

[9] Charite Univ Med Berlin, Med Clin, Berlin, Germany

[10] Univ Med Gottingen, Hematol & Med Oncol, Gottingen, Germany

[11] Ludwig Maximilians Univ Munchen, Internal Med 3, Hematol Oncol Stem Cell Transplantat, Munich, Germany

[12] Univ Cologne, Fac Med, Cologne, Germany

[13] Univ Cologne, Cologne Univ Hosp, Ctr Integrated Oncol Aachen Bonn Cologne Dusseldo, Cologne, Germany

[14] Asklepios Klin St Georg, Dept Hematol Oncol & Stem Cell Transplantat, Hamburg, Germany

[15] German Registry Stem Cell Transplantat, DRST, Ulm, Germany

[16] Univ Duisburg Essen, Inst Med Informat Biometry & Epidemiol IMIBE, Essen, Germany

[17] Univ Hosp Essen, Inst Expt Cellular Therapy, Essen, Germany

[18] Univ Med Ctr Hamburg Eppendorf, Dept Stem Cell Transplantat, Hamburg, Germany

[19] Leiden Univ, Med Ctr, Dept Biomed Data Sci, Leiden, Netherlands

[20] DKMS Clin Trials Unit, Dresden, Germany

来源：

REVISTA CHILENA DE LITERATURA | 2024年 / 109期

关键词：

D O I：

暂无

中图分类号：

I3/7 [各国文学];

学科分类号：

摘要：

Incidences of diseases treated with transplantation frequently peak at higher age. The contribution of age to total risk of transplantation has not been estimated amidst an aging society. We compare outcomes of 1,547 patients aged 70-79 years and 9,422 patients aged 60-69 years transplanted 1998-2018 for myeloid, lymphoid and further neoplasia in Germany. To quantify the contribution of population mortality to survival, we derive excess mortality based on a sex-, year- and agematched German population in a multistate model that incorporates relapse and graft -versus -host -disease (GvHD). Overall survival, relapse -free survival (RFS) and GvHD-free-relapse-free survival (GRFS) is inferior in patients aged 70-79 years, compared to patients aged 60-69 years, with 36% (95% Confidence Interval [CI]: 34-39%) versus 43% (41-44%), 32% (3035%) versus 36% (35-37%) and 23% (21-26%) versus 27% (26-28%) three years post -transplant (P<0.001). Cumulative incidences of relapse at three years are 27% (25-30%) for patients aged 70-79 versus 29% (29-30%) (60-69 years) (P=0.71), yet the difference in non -relapse mortality (NRM) (40% [38-43%] vs. 35% [34-36%] in patients aged 70-79 vs. 60-69 years) (P<0.001) translates into survival differences. Median OS of patients surviving >1 year relapse -free is 6.7 (median, 95% CI: 4.5-9.4, 70-79 years) versus 9 (8.4-10.1, 60-69 years) years since landmark. Three years after RFS of one year, excess NRM is 14% (95% CI: 12-18%) in patients aged 70-79 versus 12% [11-13%] in patients aged 60-69, while population NRM is 7% (6-7%) versus 3% (3-3%). Mortality for reasons other than relapse, GvHD, or age is as high as 27% (24-29%) and 22% (22-23%) four years after transplantation. In conclusion, survival amongst older patients is adequate after allogeneic stem cell transplantation.

引用

页码：431 / 443

页数：13

共 50 条

[1] Allogeneic hematopoietic stem cell transplantation in patients aged 60-79 years in Germany (1998-2018): a registry study
Weller, Jan Frederic
Lengerke, Claudia
Finke, Juergen
Schetelig, Johannes
Platzbecker, Uwe
Einsele, Hermann
Schroeder, Thomas
Faul, Christoph
Stelljes, Matthias
Dreger, Peter
Blau, Igor W.
Wulf, Gerald
Tischer, Johanna
Scheid, Christoph
Elmaagacli, Ahmet
Neidlinger, Helga
Flossdorf, Sarah
Bornhaeuser, Martin
Bethge, Wolfgang
Fleischhauer, Katharina
Kroeger, Nicolaus
de Wreede, Liesbeth C.
Christopeit, Maximilian
HAEMATOLOGICA, 2024, 109 (02) : 431 - 443
[2] ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR PATIENTS AGED 60 YEARS OR OLDER WITH MYELODYSPLASTIC SYNDROME IN JAPAN
Itonaga, H.
Ishiyama, K.
Aoki, J.
Aoki, K.
Ishikawa, T.
Uchida, N.
Ohashi, K.
Ueda, Y.
Fukuda, T.
Ichinohe, T.
Takanashi, M.
Atsuta, Y.
Miyazaki, Y.
LEUKEMIA RESEARCH, 2017, 55 : S26 - S26
[3] Allogeneic Hematopoietic Cell Transplantation for Myelofibrosis Aged 70 Years or Older: A Study from the German Registry for Stem Cell Transplantation
Gagelmann, Nico
Schuh, Claudia
Zeiser, Robert
Stelljes, Matthias
Bethge, Wolfgang
Wulf, Gerald
Teschner, Daniel
Klein, Stefan
Wagner-Drouet, Eva
Jost, Edgar
Dreger, Peter
Flossdorf, Sarah
Kroeger, Nicolaus
TRANSPLANTATION AND CELLULAR THERAPY, 2024, 30 (10): : 1011e1 - 1011e13
[4] Clinical Experience of Allogeneic Hematopoietic Stem Cell Transplantation in Elderly Patients Aged 60 Years and Older in South Korea
Ji, Young Sok
Ahn, Jae-Sook
Yun, Jina
Ha Jang, Geum
Lim, Sung Hee
Kim, Se Hyung
Kim, Chan Kyu
Won, Jong Ho
Park, Seong Kyu
YONSEI MEDICAL JOURNAL, 2023, 64 (02) : 123 - 132
[5] OUTCOME OF ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION IN 30 ACUTE MYELOID LEUKEMIA PATIENTS AGED 60 YEARS OR OLDER
Candoni, A.
Simeone, E.
Sperotto, A.
Tiribelli, M.
Geromin, A.
Cerno, M.
Patriarca, F.
Battista, M.
Fanin, R.
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2009, 94 : 294 - 295
[6] Allogeneic Hematopoietic Cell Transplantation (HCT) after Nonmyeloablative Conditioning for Patients (pts) Aged ≥60 Years
Sorror, Mohamed L.
Storer, Barry
Sandmaier, Brenda M.
Maloney, David G.
Franke, Georg
Shizuru, Judith
Chauncey, Thomas
Agura, Edward
Maziarz, Richard T.
Sahebi, Firoozeh
Langston, Amelia A.
Wade, James C.
Maris, Michael
Bruno, Benedetto
Yeager, Andrew M.
Pulsipher, Michael
Petersen, Finn
Bethge, Wolfgang A.
McSweeney, Peter A.
Niederwieser, Dietger
Blume, Karl G.
Storb, Rainer F.
BLOOD, 2008, 112 (11) : 753 - 754
[7] Increased opportunity for prolonged survival after allogeneic hematopoietic stem cell transplantation in patients aged 60–69 years with myelodysplastic syndrome
Hidehiro Itonaga
Ken Ishiyama
Kazunari Aoki
Jun Aoki
Takayuki Ishikawa
Naoyuki Uchida
Kazuteru Ohashi
Yasunori Ueda
Takahiro Fukuda
Toru Sakura
Yuju Ohno
Koji Iwato
Hirokazu Okumura
Tadakazu Kondo
Tatsuo Ichinohe
Minoko Takanashi
Yoshiko Atsuta
Yasushi Miyazaki
Annals of Hematology, 2019, 98 : 1367 - 1381
[8] Allogeneic stem cell transplantation for myelofibrosis patients aged ≥65 years
Daghia, Giulia
Zabelina, Tatjana
Zeck, Gaby
von Pein, Ute-Marie
Christopeit, Maximilian
Wolschke, Christine
Ayuk, Francis
Kroeger, Nicolaus
EUROPEAN JOURNAL OF HAEMATOLOGY, 2019, 103 (04) : 370 - 378
[9] Risk factors for cytomegalovirus infection of 79 allogeneic hematopoietic stem cell transplantation patients
Tan, Y.
Liu, X.
Zhao, Y.
Su, L.
Liu, Y.
Gao, S.
BONE MARROW TRANSPLANTATION, 2016, 51 : S406 - S406
[10] Increased opportunity for prolonged survival after allogeneic hematopoietic stem cell transplantation in patients aged 60-69years with myelodysplastic syndrome
Itonaga, Hidehiro
Ishiyama, Ken
Aoki, Kazunari
Aoki, Jun
Ishikawa, Takayuki
Uchida, Naoyuki
Ohashi, Kazuteru
Ueda, Yasunori
Fukuda, Takahiro
Sakura, Toru
Ohno, Yuju
Iwato, Koji
Okumura, Hirokazu
Kondo, Tadakazu
Ichinohe, Tatsuo
Takanashi, Minoko
Atsuta, Yoshiko
Miyazaki, Yasushi
ANNALS OF HEMATOLOGY, 2019, 98 (06) : 1367 - 1381

← 1 2 3 4 5 →