Technological development of multidimensional liquid chromatography-mass spectrometry in proteome research

被引:3
|
作者
Yu, Hailong [1 ]
Tai, Qunfei [1 ]
Yang, Chenjie [1 ]
Gao, Mingxia [1 ]
Zhang, Xiangmin [1 ]
机构
[1] Fudan Univ, Dept Chem, Shanghai 200438, Peoples R China
基金
国家重点研发计划;
关键词
Multidimensional liquid chromatography; MDLC-MS; Proteomics; Automation; Protein -protein interactions; RETENTION TIME PREDICTION; HIGH-ABUNDANCE PROTEINS; TOP-DOWN PROTEOMICS; HIGH-PERFORMANCE; HYDROPHILIC INTERACTION; PEPTIDE FRACTIONATION; MICROFLUIDIC DEVICES; IDENTIFICATION; SEPARATION; DEPLETION;
D O I
10.1016/j.chroma.2023.464048
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Liquid chromatography-mass spectrometry (LC-MS) is the method of choice for high-throughput pro-teomic research. Limited by the peak capacity, the separation performance of conventional single -dimensional LC hampers the development of proteomics. Combining different separation modes orthogo-nally, multidimensional liquid chromatography (MDLC) with high peak capacity was developed to address this challenge. MDLC has evolved rapidly since its establishment, and the progress of proteomics has been greatly facilitated by the advent of novel MDLC-MS-based methods. In this paper, we will review the advances of MDLC-MS-based methodologies and technologies in proteomics studies, from different per-spectives including novel application scenarios and proteomic targets, automation, miniaturization, and the improvement of the classic methods in recent years. In addition, attempts regarding new MDLC-MS models are also mentioned together with the outlook of MDLC-MS-based proteomics methods.(c) 2023 Elsevier B.V. All rights reserved.
引用
收藏
页数:11
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