Patient Comfort During Postop Period in Breast Cancer Surgeries: A Randomized Controlled Trial Comparing Opioid and Opioid-Free Anesthesia

被引:1
|
作者
Yuvaraj, Aravindhan Krishnasamy [1 ]
Gayathri, Balasubramaniam [1 ]
Balasubramanian, Natarajan [1 ]
Mirunalini, Gunaseelan [1 ]
机构
[1] SRM Med Coll Hosp & Res Ctr, Anaesthesiol, Chennai, India
关键词
opioid free anesthesia; pain; emotions; quality of recovery; modified radical mastectomy; opioids; RECOVERY; QUALITY;
D O I
10.7759/cureus.33871
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Anesthetic management practices have advanced to opioid-free anesthesia (OFA) often replacing opioids in oncologic surgeries. The study was conducted to find the quality of recovery (QoR) of patients undergoing breast cancer surgeries receiving OFA. Methods: A double-blinded, randomized controlled study was conducted with 60 patients randomized to group OFA and group OA (opioid anesthesia). Group OFA received one-time dosing of ketamine 0.3 mg/kg, lignocaine 1.5 mg/kg, and dexmedetomidine 1 mcg/kg. Group OA received fentanyl 2mcg/kg. Intraoperatively, Group OFA received dexmedetomidine 0.4 mcg/kg/h and the OA group received fentanyl 0.5 mcg/kg/h infusion. Bispectral index (BIS), hemodynamics, muscle relaxant administration, and sevoflurane concentration were noted. A modified QoR-40 score was used to assess the quality of recovery in the postoperative period. Results: A higher QoR-40 score was found in the OA group (median 182, IQR 178-186) compared to the OFA group (median 180, IQR 178-184). Out of the five components, the patient's emotional state was better in the group OA (39.9 +/- 2.77) than in the OFA group (37.9 +/- 2.77). The patient's physical comfort was found to be better in the group OFA (52.52 +/- 3.23) compared to group OA (50.93 +/- 3.23). Physical independence, psychological support, and pain were comparable between the two groups. Patients in group OFA received less sevoflurane, a muscle relaxant, and showed a mild reduction in heart rate and mean arterial pressure (MAP) when compared to group OA. The time taken to reach a Modified Aldrete score of 9 was high in OFA (11.47 +/- 2.16) and (9.17 +/- 1.09) when compared to group OA. No significant differences were noted with the visual analog score (VAS) score, Ramsay sedation score, and modified post-anesthesia discharge scoring system (PADSS) score.Conclusion: We conclude that the quality of recovery of patients receiving opioid-free methods of anesthesia was not inferior to OA in patients undergoing breast cancer surgeries.
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页数:7
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