Carrier systems of radiopharmaceuticals and the application in cancer therapy

被引:3
|
作者
Zhang, Taotao [1 ,2 ,3 ,4 ]
Lei, Huiwen [1 ,2 ,3 ,4 ]
Chen, Xiaohua [1 ,2 ,3 ,4 ,5 ]
Dou, Zhihui [1 ,2 ,3 ,4 ]
Yu, Boyi [1 ,2 ,3 ,4 ]
Su, Wei [1 ,2 ,3 ,4 ]
Wang, Wei [6 ]
Jin, Xiaodong [1 ,5 ]
Katsube, Takanori [7 ]
Wang, Bing [7 ]
Zhang, Hong [1 ,2 ,3 ,4 ,5 ]
Li, Qiang [1 ,2 ,3 ,4 ,5 ]
Di, Cuixia [1 ,2 ,3 ,4 ,5 ]
机构
[1] Chinese Acad Sci, Inst Modern Phys, Biomed Res Ctr, Lanzhou 730000, Peoples R China
[2] Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China
[3] Univ Chinese Acad Sci, Coll Life Sci, Beijing 101408, Peoples R China
[4] Univ Chinese Acad Sci, Sch Nucl Sci & Technol, Beijing 101408, Peoples R China
[5] Adv Energy Sci & Technol Guangdong Lab, Huizhou 516029, Peoples R China
[6] Northwest Normal Univ, Coll Life Sci, Lanzhou 730000, Peoples R China
[7] Natl Inst Quantum Sci & Technol, Natl Inst Radiol Sci, Chiba 2638555, Japan
基金
中国国家自然科学基金;
关键词
NON-HODGKINS-LYMPHOMA; TARGETED RADIONUCLIDE THERAPY; SOMATOSTATIN RECEPTOR AGONIST; PRETARGETED RADIOIMMUNOTHERAPY; IN-VIVO; PROSTATE-CANCER; PRECLINICAL EVALUATION; CLINICAL-EVALUATION; GOLD NANOPARTICLES; THERANOSTIC AGENTS;
D O I
10.1038/s41420-023-01778-3
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Radiopharmaceuticals play a vital role in cancer therapy. The carrier of radiopharmaceuticals can precisely locate and guide radionuclides to the target, where radionuclides kill surrounding tumor cells. Effective application of radiopharmaceuticals depends on the selection of an appropriate carrier. Herein, different types of carriers of radiopharmaceuticals and the characteristics are briefly described. Subsequently, we review radiolabeled monoclonal antibodies (mAbs) and their derivatives, and novel strategies of radiolabeled mAbs and their derivatives in the treatment of lymphoma and colorectal cancer. Furthermore, this review outlines radiolabeled peptides, and novel strategies of radiolabeled peptides in the treatment of neuroendocrine neoplasms, prostate cancer, and gliomas. The emphasis is given to heterodimers, bicyclic peptides, and peptide-modified nanoparticles. Last, the latest developments and applications of radiolabeled nucleic acids and small molecules in cancer therapy are discussed. Thus, this review will contribute to a better understanding of the carrier of radiopharmaceuticals and the application in cancer therapy.
引用
收藏
页数:14
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