Role of Rho GTPases in inflammatory bowel disease

被引：6

作者：

Li, Xiaoling ^{[1
]}

Zhang, Mudan ^{[1
]}

Zhou, Gaoshi ^{[1
]}

Xie, Zhuo ^{[1
]}

Wang, Ying ^{[1
]}

Han, Jing ^{[1
]}

Li, Li ^{[1
]}

Wu, Qirui ^{[1
]}

Zhang, Shenghong ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Affiliated Hosp 1, Div Gastroenterol, Guangzhou, Peoples R China

来源：

CELL DEATH DISCOVERY | 2023年 / 9卷 / 01期

基金：

中国国家自然科学基金;

关键词：

SINGLE NUCLEOTIDE POLYMORPHISMS; EPITHELIAL BARRIER FUNCTION; KAPPA-B ACTIVATION; DIVISION CYCLE 42; T-CELL MIGRATION; DENDRITIC CELLS; CROHNS-DISEASE; ULCERATIVE-COLITIS; PROINFLAMMATORY CYTOKINES; ENTERIC PATHOGENS;

D O I：

10.1038/s41420-023-01329-w

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Rat sarcoma virus homolog (Rho) guanosine triphosphatases (GTPases) function as "molecular switch" in cellular signaling regulation processes and are associated with the pathogenesis of inflammatory bowel disease (IBD). This chronic intestinal tract inflammation primarily encompasses two diseases: Crohn's disease and ulcerative colitis. The pathogenesis of IBD is complex and considered to include four main factors and their interactions: genetics, intestinal microbiota, immune system, and environment. Recently, several novel pathogenic components have been identified. In addition, potential therapies for IBD targeting Rho GTPases have emerged and proven to be clinically effective. This review mainly focuses on Rho GTPases and their possible mechanisms in IBD pathogenesis. The therapeutic possibility of Rho GTPases is also discussed.

引用

页数：13

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