Pillars of biology: Boolean modeling of gene-regulatory networks

被引：0
|
作者：
Thakar, Juilee [1 ,2 ]
机构：
[1] Univ Rochester, Sch Med & Dent, Dept Microbiol & Immunol, Rochester, NY 14627 USA
[2] Univ Rochester, Sch Med & Dent, Dept Biostat & Computat Biol, Rochester, NY 14627 USA
来源：
JOURNAL OF THEORETICAL BIOLOGY | 2024年 / 578卷
关键词：
Boolean modeling; Discrete -state modeling; Gene-regulatory networks;
D O I：
10.1016/j.jtbi.2023.111682
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Boolean modeling is a mathematical modeling framework used for defining and studying gene-regulatory networks (GRNs). It serves as a means to develop mechanistic models, offering insights into the trajectories and dynamic properties of GRNs. In this review, I delve into seminal papers published in the Journal of Theoretical Biology that have spearheaded this field. Additionally, I explore the application of these modeling methods in the current era of data-intensive science.
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页数：3
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