New nor-chamigrane and bisabolane sesquiterpenoids from the sea hare Aplysia dactylomela

被引：3

作者：

Binh, Pham Thanh ^{[1
,2
]}

Trang, Duong Thu ^{[2
]}

Trung, Vu Thanh ^{[1
,2
]}

Linh, Kieu Thi Phuong ^{[2
]}

Phong, Nguyen Viet ^{[2
]}

Thao, Nguyen Phuong ^{[1
,2
]}

Cuong, Nguyen Xuan ^{[1
,2
]}

Thung, Do Cong ^{[3
]}

Nam, Nguyen Hoai ^{[1
,2
]}

Thanh, Nguyen Van ^{[1
,2
,4
]}

机构：

[1] Grad Univ Sci & Technol, Vietnam Acad Sci & Technol VAST, 18 Hoang Quoc Viet, Hanoi, Vietnam

[2] VAST, Inst Marine Biochem IMBC, 18 Hoang Quoc Viet, Hanoi, Vietnam

[3] VAST, Inst Marine Environm & Resources, Haiphong, Vietnam

[4] Vietnam Acad Sci & Technol VAST, Inst Marine Biochem IMBC, 18 Hoang Quoc Viet, Hanoi, Vietnam

来源：

PHYTOCHEMISTRY LETTERS | 2023年 / 53卷

关键词：

Nor-chamigrane; Bisabolane derivative; Sesquiterpene; Aplysia dactylomela; Sea hare; RED ALGA; LAURENCIA; CONSTITUENTS;

D O I：

10.1016/j.phytol.2022.11.016

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new nor-chamigranes and a new bisabolane sesquiterpene, given the trivial names dactylomelanins C-E (1-3), were isolated from the sea hare Aplysia dactylomela along with a known compound (4). Their structures and absolute configurations were elucidated by analysis of their HRESIMS, NMR and ECD spectroscopic data. The position of the bromine atom in the structure of 1 was established by quantum chemical calculations of the NMR chemical shifts and by analysis of DP4+ probability. Compounds 1-4 were evaluated for their cytotoxicity against three cell lines, A549, MCF-7, and HepG2.

引用

页码：92 / 97

页数：6

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