Association of Polycystic Ovarian Syndrome with Endometrial Carcinoma among Premenopausal Females

Objective: To determine the association of polycystic ovarian syndrome (PCOS) with endometrial carcinoma in premenopausal females. Study Design: Cohort study. Place and Duration of the Study: Department of Obstetrics and Gynaecology, Unit II, Sir Ganga Ram Hospital, Lahore, Pakistan, from July 2020 to January 2021. Methodology: Females aged between 20-45 years, presenting with irregular uterine bleeding were included. Females with PCOS were considered as the exposed group and females without PCOS were considered as the unexposed group. Dilation and curettage was performed, and histopathology reports were assessed. Results: There were total 70 patients (35 in each group). The mean age was 34.93 +/- 8.64 years in the exposed and 30.92 +/- 5.98 years in the unexposed group. Frequency percentage of endometrial carcinoma was 34.3 % (n=24) in the exposed and 15.7% (n=11) in the unexposed group (OR=10.54). Conclusion: PCOS was found to be one of the risk factors for endometrial carcinoma.