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Grenoble Alpes Univ, Host Pathogen Interact & Immun Infect, Inst Adv Biosci IAB, INSERM U1209,CNRS UMR 5309, Grenoble, France Grenoble Alpes Univ, Host Pathogen Interact & Immun Infect, Inst Adv Biosci IAB, INSERM U1209,CNRS UMR 5309, Grenoble, France