Human Plasma Cells Engineered to Produce Bi-Specific T Cell Engagers Show In Vivo Anti-Tumor Efficacy

被引：0
|
作者：
Hill, Tyler [1 ]
Narvekar, Parnal [1 ]
Asher, Gregory [1 ]
Camp, Nathan [1 ]
Thomas, Kerri [1 ]
Tasian, Sarah [2 ,3 ]
Rawlings, David J. [4 ,5 ,6 ]
James, Richard [4 ,5 ,7 ]
机构：
[1] Seattle Childrens Res Inst Seattle, Seattle, WA USA
[2] Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA USA
[3] Univ Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA USA
[4] Seattle Childrens Res Inst, Seattle, WA USA
[5] Univ Washington, Dept Pediat, Seattle, WA USA
[6] Univ Washington, Dept Immunol, Seattle, WA USA
[7] Univ Washington, Dept Pharmacol, Seattle, WA USA
来源：
MOLECULAR THERAPY | 2023年 / 31卷 / 04期
关键词：
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
575
引用
收藏
页码：290 / 290
页数：1
相关论文
共 50 条
  • [1] Novel Bi-Specific Immuno-Modulatory Tribodies Potentiate T Cell Activation and Increase Anti-Tumor Efficacy
    Passariello, Margherita
    Yoshioka, Asami
    Takahashi, Kota
    Hashimoto, Shu-ichi
    Lembo, Rosa Rapuano
    Manna, Lorenzo
    Nakamura, Koji
    De Lorenzo, Claudia
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (07)
  • [2] Real Time Monitoring of Human Primary Cell Panel for Evaluating On/Off Target Toxicity of Bi-Specific T Cell Engagers.
    Jin, C.
    Abassi, Y.
    MOLECULAR BIOLOGY OF THE CELL, 2018, 29 (26)
  • [3] Murine colon carcinoma cells engineered to produce human interleukin-2 induce tumor-specific anti-tumor response
    Gunji, Y
    Tagawa, M
    Matsubara, H
    Takenaga, K
    Shimada, H
    Kondo, F
    Suzuki, T
    Nakajima, K
    Aoki, T
    Asano, T
    Ochiai, T
    Isono, K
    Kageyama, H
    Nakamura, Y
    Sakiyama, S
    INTERNATIONAL JOURNAL OF CANCER, 1996, 66 (01) : 135 - 139
  • [4] Role of naive and memory T cells in tumor cell lysis mediated by bi-specific antibodies
    Renner, C
    Held, G
    Ohnesorge, S
    Bauer, S
    Gerlach, K
    Pfitzenmeier, JP
    Pfreundschuh, M
    IMMUNOBIOLOGY, 1997, 197 (01) : 122 - 132
  • [5] Bi-specific autoantigen-T cell engagers as targeted immunotherapy for autoreactive B cell depletion in autoimmune diseases
    Perico, Luca
    Casiraghi, Federica
    Sonego, Fabiane
    Todeschini, Marta
    Corna, Daniela
    Cerullo, Domenico
    Pezzotta, Anna
    Isnard-Petit, Patricia
    Faravelli, Silvia
    Forneris, Federico
    Thiam, Kader
    Benigni, Ariela
    Remuzzi, Giuseppe
    FRONTIERS IN IMMUNOLOGY, 2024, 15
  • [6] Anti-Tumor Effects of Chimeric Receptor Engineered Human T Cells Directed to Tumor Stroma
    Kakarla, Sunitha
    Chow, Kevin
    Mata, Melinda
    Song, Xiao-Tong
    Wu, Men-Feng
    Liu, Hao
    Wang, Lisa
    Rowley, David
    Pfizenmaier, Klaus
    Gottschalk, Stephen
    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2013, 19 (02) : S348 - S349
  • [7] ANTI-TUMOR IN VIVO EFFICACY OF T CELLS TRANSDUCED WITH MAGE-A4-SPECIFIC αβ TYPE TCR GENES
    Ikeda, Hiroaki
    Shirakura, Yoshitaka
    Hirayama, Michiko
    Hiasa, Atsunori
    Nishikawa, Hiroyoshi
    Kitano, Shigehisa
    Tajima, Kazuo
    Nukaya, Ikuei
    Yu, Shen Sin
    Mineno, Junichi
    Ito, Mamoru
    Kato, Ikunoshin
    Shiku, Hiroshi
    JOURNAL OF GENE MEDICINE, 2009, 11 (12): : 1163 - 1163
  • [8] Overcoming Tumor Immune Escape Using Bi-Specific CAR T Cells
    Anurathapan, Usanarat
    Hindi, Hakeem F.
    Muchala, Roopa
    Rooney, Cliona
    Brenner, Malcolm K.
    Leen, Ann M.
    Vera, Juan F.
    MOLECULAR THERAPY, 2012, 20 : S34 - S34
  • [9] Engineered T cells secreting anti-BCMA T cell engagers control multiple myeloma and promote immune memory in vivo
    Diez-Alonso, Laura
    Falgas, Aida
    Arroyo-Rodenas, Javier
    Romencin, Paola A.
    Martinez, Alba
    Gomez-Rosel, Marina
    Blanco, Belen
    Jimenez-Reinoso, Anais
    Mayado, Andrea
    Perez-Pons, Alba
    Aguilar-Sopena, Oscar
    Ramirez-Fernandez, Angel
    Segura-Tudela, Alejandro
    Perez-Amill, Lorena
    Tapia-Galisteo, Antonio
    Dominguez-Alonso, Carmen
    Rubio-Perez, Laura
    Jara, Maria
    Sole, Francesc
    Hangiu, Oana
    Almagro, Laura
    Albitre, Angela
    Penela, Petronila
    Sanz, Laura
    Anguita, Eduardo
    Valeri, Antonio
    Garcia-Ortiz, Almudena
    Rio, Paula
    Juan, Manel
    Martinez-Lopez, Joaquin
    Roda-Navarro, Pedro
    Martin-Antonio, Beatriz
    Orfao, Alberto
    Menendez, Pablo
    Bueno, Clara
    alvarez-Vallina, Luis
    SCIENCE TRANSLATIONAL MEDICINE, 2024, 16 (734)
  • [10] Ex Vivo Enriched Tumor Antigen-Specific T Cells Are Optimal Effectors of T Cell Engagers and Tumor-Specific T Cell Receptor/T Cell Engager Combination Provides Synergistic Efficacy Against Hematologic Malignancies
    Bariana, Manpreet
    Batistick, Mark
    Oelke, Mathias
    Kim, Sojung
    Cassella, Elena
    Anand, Sidharth
    Anuncio, Shaina
    Varkey, Ashley
    Wang, Ruipeng
    Ragheb, Jack
    Siegel, David
    Zakrzewski, Johannes
    BLOOD, 2023, 142
12345