Biomedical applications of engineered heparin-based materials

被引：19

作者：

Zare, Ehsan Nazarzadeh ^{[1
]}

Khorsandi, Danial ^{[2
]}

Zarepour, Atefeh ^{[3
]}

Yilmaz, Hulya ^{[6
]}

Agarwal, Tarun ^{[5
]}

Hooshmand, Sara ^{[6
]}

Mohammadinejad, Reza ^{[7
]}

Ozdemir, Fatma ^{[6
]}

Sahin, Onur ^{[4
]}

Adiguzel, Sevin ^{[6
]}

Khan, Haroon ^{[8
]}

Zarrabi, Ali ^{[3
]}

Sharifi, Esmaeel ^{[9
,10
]}

Kumar, Arun ^{[11
]}

Mostafavi, Ebrahim ^{[12
,13
]}

Kouchehbaghi, Negar Hosseinzadeh ^{[2
]}

Mattoli, Virgilio ^{[14
]}

Zhang, Feng ^{[15
]}

Jucaud, Vadim ^{[2
]}

Najafabadi, Alireza Hassani ^{[2
]}

Khademhosseini, Ali ^{[2
]}

机构：

[1] Damghan Univ, Sch Chem, Damghan 3671645667, Iran

[2] Terasaki Inst Biomed Innovat, Los Angeles, CA 90024 USA

[3] Istinye Univ, Fac Engn & Nat Sci, Dept Biomed Engn, TR-34396 Istanbul, Turkiye

[4] Istinye Univ, Fac Pharm, Dept Basic Pharm Sci, Istanbul, Turkiye

[5] Koneru Lakshmaiah Educ Fdn, Dept Biotechnol, Vaddeswaram, Andhra Pradesh, India

[6] Sabanci Univ, Nanotechnol Res & Applicat Ctr SUNUM, TR-34956 Istanbul, Turkiye

[7] Kerman Univ Med Sci, Res Ctr Trop & Infect Dis, Kerman, Iran

[8] Abdul Wali Khan Univ, Dept Pharm, Mardan 23200, Pakistan

[9] Hamadan Univ Med Sci, Sch Adv Med Sci & Technol, Dept Tissue Engn & Biomat, Hamadan, Iran

[10] CNR, Inst Polymers Composites & Biomat, IPCB, CNR, Viale JF Kennedy 54, Mostra DOltremare Pad 20, I-80125 Naples, Italy

[11] Chitkara Univ, Chitkara Coll Pharm, Rajpura, Punjab, India

[12] Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA

[13] Stanford Univ, Sch Med, Stanford Cardiovasc Inst, Stanford, CA 94305 USA

[14] Ist Italiano Tecnol, Ctr Mat Interfaces, Viale Rinaldo Piaggio 34, I-56025 Pisa, Italy

[15] Wenzhou Med Univ, Quzhou Affiliated Hosp, Quzhou Peoples Hosp, Quzhou 324000, Zhejiang, Peoples R China

来源：

BIOACTIVE MATERIALS | 2024年 / 31卷

关键词：

Heparin; Nanomaterials; Physicochemical; Biological; Preparation; MOLECULAR-WEIGHT HEPARIN; ENDOTHELIAL PROGENITOR CELLS; DRUG-DELIVERY-SYSTEM; CROSS-LINKING; BLOCKING VEGF; LUNG-CANCER; SCAFFOLDS; HYDROGELS; NANOPARTICLES; ANTICOAGULANT;

D O I：

10.1016/j.bioactmat.2023.08.002

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Heparin is a negatively charged polysaccharide with various chain lengths and a hydrophilic backbone. Due to its fascinating chemical and physical properties, nontoxicity, biocompatibility, and biodegradability, heparin has been extensively used in different fields of medicine, such as cardiovascular and hematology. This review highlights recent and future advancements in designing materials based on heparin for various biomedical ap-plications. The physicochemical and mechanical properties, biocompatibility, toxicity, and biodegradability of heparin are discussed. In addition, the applications of heparin-based materials in various biomedical fields, such as drug/gene delivery, tissue engineering, cancer therapy, and biosensors, are reviewed. Finally, challenges, opportunities, and future perspectives in preparing heparin-based materials are summarized.

引用

页码：87 / 118

页数：32

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