An observational comparative study of clinicoepidemiological profile of COVID-19 patients admitted in the tertiary care hospital during first and second wave on pandemic

Background: The World Health Organization declared COVID-19 a global pandemic on March 11, 2020. India confirmed its first case of COVID-19 on 30 January and within 8 weeks the total number of cases had crossed the 1000 mark. Methods: An Observational comparative study was done to see the clinic epidemiological profile, and identify the determinants of COVID 19 patients admitted in the hospital in the last 1 year in both the first and second waves with respect to. All individuals testing positive for severe acute respiratory syndrome coronavirus 2 RNA using reverse transcription polymerase chain reaction were included. Results: A total of 1710 was hospitalized, 701 (40.9%) and 1009 (59.1%) were involved in first and second wave. The mean age was 42.58 +/- 13.99 and 45.32 +/- 14.18 and majority of them were belong to the 20-60 years and the comparison was showing statistically significant (P = 0.004). The participants affected with the risk factors like smoking 276 (27.3) and alcohol 237 (23.5) with P < 0.0001. The duration of stay was (median 6 [inter quartile range (IQR) 3-7] days in the first wave vs. median 7 [IQR 3-9] days in the second wave; P < 0.001). Conclusion: The second wave had shown more aggressive nature in spreading the COVID-19 infection than the first wave. Besides the steep rise of the cases, there has been more among the patients with commodities and risk factors in the second wave.