Planar Chiral Ferrocendiyl and Ruthenocendiyl Bisimidazoline Bispalladacycles Featuring Pyridin-2-olates and Ketophenolates as Potentially Hemilabile Ligands in Asymmetric 1,4-Additions

被引:0
|
作者
Dorst, Konstantin [1 ]
Frey, Wolfgang [1 ]
Peters, Rene [1 ]
机构
[1] Univ Stuttgart, Inst Organ Chem, Pfaffenwaldring 55, D-70569 Stuttgart, Germany
关键词
coordination behavior; ferrocene; hemilabile ligand; palladium; pyridonate; AZA-CLAISEN REARRANGEMENT; MICHAEL ADDITIONS; ALLYLIC ALCOHOLS; IN-SITU; PALLADACYCLE; CATALYSIS;
D O I
10.1002/ejic.202300748
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Planar chiral bispalladacycles based on ferrocene have previously been shown to be excellent catalysts for asymmetric 1,4-additions of alpha-cyanoacetates to enones. For a bimetallic reaction pathway, it was found that product decomplexation is probably rate-determining as a result of a bimetallic two-point binding. We hypothesized that the use of hemilabile chelating ligands might accelerate this step to improve the catalytic activity. Here we report the use of pyridin-2-olates (pyridonates) as potentially hemilabile 1,3-N,O-chelating ligands in this catalytic application. In this article, we describe the first coordination of pyridonate ligands to planar chiral, metallocene based palladacycles. Four of the resulting ferrocene and ruthenocene bis-palladium complexes were characterized by X-ray single crystal structure analysis revealing a mu 2-(O,N) coordination mode. We suggest that an observed lower catalytic efficiency of the new complexes has its origin in this particular coordination mode. For that reason, a related trifluoromethylketophenolate ligand was installed for which kappa 2-(O,N) coordination was expected and also experimentally found. Indeed, in that case catalytic activity was improved compared to the benchmark system. The coordination of pyridonates and a ketophenolate to metallocene based bispalladacycles is reported. Using the phenolate ligand in a catalytic asymmetric 1,4-addition, higher activity than with the benchmark system from literature was found, while the pyridonate decreased the activity. The different mu 2- and kappa 2-coordination modes are discussed as reason. image
引用
收藏
页数:7
相关论文
共 1 条
  • [1] Hemilabile P-Alkene Ligands in Chiral Rhodium and Copper Complexes: Catalytic Asymmetric 1,4 Additions to Enones. 2
    Drinkel, Emma
    Briceno, Alexander
    Dorta, Reto
    Dorta, Romano
    ORGANOMETALLICS, 2010, 29 (11) : 2503 - 2514