Genetic and Epigenetic Factors in Gestational Diabetes Mellitus Pathology

被引：1

作者：

Ustianowski, Lukasz ^{[1
]}

Udzik, Jakub ^{[1
,2
]}

Szostak, Joanna ^{[3
]}

Goracy, Anna ^{[4
]}

Ustianowska, Klaudia ^{[1
]}

Pawlik, Andrzej ^{[1
]}

机构：

[1] Pomeranian Med Univ, Dept Physiol, PL-70111 Szczecin, Poland

[2] Pomeranian Med Univ, Dept Cardiac Surg, PL-70111 Szczecin, Poland

[3] Pomeranian Med Univ, Dept Expt & Clin Pharmacol, PL-70111 Szczecin, Poland

[4] Pomeranian Med Univ, Dept Clin & Mol Biochem, PL-70111 Szczecin, Poland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 23期

关键词：

gestational diabetes; genetics; epigenetics; HEPATOCYTE NUCLEAR FACTOR-1-ALPHA; BETA(3)-ADRENERGIC RECEPTOR; INSULIN-RECEPTOR; TRP(64)ARG POLYMORPHISM; GLUCOKINASE MUTATIONS; GLUCOSE-METABOLISM; DNA METHYLATION; ADIPOSE-TISSUE; YOUNG MODY; EXPRESSION;

D O I：

10.3390/ijms242316619

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gestational diabetes (GDM) is the carbohydrate intolerance occurring during pregnancy. The risk factors of GDM include obesity, advanced maternal age, polycystic ovary syndrome, multigravidity, a sedentary lifestyle, and pre-existing hypertension. Additionally, complex genetic and epigenetic processes are also believed to play a crucial role in the development of GDM. In this narrative review, we discuss the role of genetic and epigenetic factors in gestational diabetes mellitus pathogenesis.

引用

页数：15

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