Metal-free C-3 selective C(sp2)-C(sp3) heteroarylation of anilines with imidazo[1,2-a]pyridine derivatives via cross-dehydrogenative coupling

被引：2

作者：

Wang, Kai ^{[1
,2
]}

Du, Xiaoxue ^{[1
,2
]}

Zhang, Pengfei ^{[3
]}

Wei, Zhenjiang ^{[4
]}

Cao, Xian-Ting ^{[1
,2
]}

机构：

[1] Jining Med Univ, Coll Med Engn, Jining 272067, Peoples R China

[2] Jining Med Univ, Key Lab Med Funct Nanomat, Jining 272067, Peoples R China

[3] Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Key Lab Organosilicon Chem & Mat Technol, Hangzhou 311121, Peoples R China

[4] Shandong Med Technician Coll, Dept Pharmaceut Engn, Tai An 271016, Peoples R China

来源：

RSC ADVANCES | 2023年 / 13卷 / 31期

关键词：

C-H; BOND FORMATION; N-HYDROXYPHTHALIMIDE; WATER; HETEROCYCLES; ACTIVATION; ALKYLATION; AMINATION; EVOLUTION; STRATEGY;

D O I：

10.1039/d3ra03852a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A general and straightforward method for the regioselective construction of C-3 heteroaryl-containing imidazo[1,2-a]pyridines via cross-dehydrogenative coupling under transition-metal-free conditions has been reported, utilizing N,N-dimethylaniline as the methylenation source and furnishing the C(sp(2))-C(sp(3)) functionalized products in good to excellent yields. Mechanism studies indicate that a radical pathway is responsible for this transformation.

引用

页码：21685 / 21689

页数：5

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