Supernatural: Artificial Nucleobases and Backbones to Program Hybridization-Based Assemblies and Circuits

被引：12

作者：

Lopez-Tena, Miguel ^{[1
]}

Chen, Si-Kai ^{[1
]}

Winssinger, Nicolas ^{[1
]}

机构：

[1] Univ Geneva, Fac Sci, Dept Organ Chem, NCCR Chem Biol, CH-1205 Geneva, Switzerland

来源：

BIOCONJUGATE CHEMISTRY | 2023年 / 34卷 / 01期

关键词：

AMP Exception; PEPTIDE NUCLEIC-ACID; TRIPLEX-FORMING OLIGONUCLEOTIDES; HELICAL RECOGNITION; DNA NANOTECHNOLOGY; EPIGENETIC MODIFICATION; TEMPLATED REACTIONS; POLYPURINE TRACTS; CYTOSINE ANALOG; MAJOR GROOVE; CENTER-DOT;

D O I：

10.1021/acs.bioconjchem.2c00292

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The specificity and predictability of hybridization make oligonucleotides a powerful platform to program assemblies and networks with logic-gated responses, an area of research which has grown into a field of its own. While the field has capitalized on the commercial availability of DNA oligomers with its four canonical nucleobases, there are opportunities to extend the capabilities of the hardware with unnatural nucleobases and other backbones. This Topical Review highlights nucleobases that favor hybridizations that are empowering for assemblies and networks as well as two chiral XNAs than enable orthogonal hybridization networks.

引用

页码：111 / 123

页数：13