Formulation and In vitro Evaluation of Carica Papaya Topical Gel

Drug delivery through the skin can be used for efficiently treating local dermatological disorders. Topical gel preparations offer an appropriate drug delivery since they are less oily and easily pull away from the skin. Oral delivery has first-pass impacts, gastrointestinal discomfort, and metabolic degradation as negatives. The topical administration of gel formulations has been suggested as a way to get over these obstacles. The current study is concerned with formulation and In vitro evaluation of C. Papaya topical gel. A tropical plant called Carica Papaya [C. Papaya] has been used for a long time to treat a number of illnesses, including inflammatory conditions. Gastrointestinal issues are the NSAIDs' most significant side effects. In an effort to combat this, a topical gel was created utilizing papaya extract, which is known to cure inflammation. Gels are becoming a top-tier material, as a result of its biocompatibility, network topology, and molecular stability of the included bioactive ingredient, employed for drug delivery formulations. Maceration was the process employed to create the C. Papaya extract, and several polymers, including Carbopol 934, xanthan gum, and guar gum, were used in various proportions to develop the topical gel. The topical gel was prepared by using dispersion method. A total number of six formulations were developed employing 1:1 and 1:5 ratios. It appears that there is no interaction between the extract and the formulation's polymers, according to FT-IR measurements. The topical gel's physical characteristics, viscosity, diffusion studies, pH, and spreadability were assessed and were found to be satisfactory. All of the formulations' viscosities were between 32.3 and 36.4 Cps. Among all formulations, formulation F2 containing 1.5% of Carbopol 934 which shows 98.7% of the drug was released, making it the formulation with the greatest chance of success.