Screening for Biomarkers Associated with Left Ventricular Function During Follow-up After Acute Coronary Syndrome

被引：3
|
作者：
Christersson, Christina [1 ]
Baron, Tomasz [1 ]
Flachskampf, Frank [1 ]
Lindhagen, Lars [2 ]
Lindahl, Bertil [1 ,2 ]
Siegbahn, Agneta [3 ]
机构：
[1] Uppsala Univ, Dept Med Sci, Cardiol, SE-75185 Uppsala, Sweden
[2] Uppsala Univ, Uppsala Clin Res Ctr, Uppsala, Sweden
[3] Uppsala Univ, Dept Med Sci, Clin Chem, Uppsala, Sweden
来源：
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | 2023年 / 16卷 / 01期
关键词：
Soluble biomarkers; Left ventricular function; Acute coronary syndrome; Heart failure; GLOBAL LONGITUDINAL STRAIN; PLASMINOGEN-ACTIVATOR RECEPTOR; ACUTE MYOCARDIAL-INFARCTION; CHRONIC HEART-FAILURE; PROGNOSTIC VALUE; EJECTION FRACTION; IRON-DEFICIENCY; OSTEOPONTIN; REPERFUSION; ECHOCARDIOGRAPHY;
D O I：
10.1007/s12265-022-10285-2
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A proportion of patients with the acute coronary syndrome (ACS) will suffer progressive remodeling of the left ventricular (LV). The aim was to screen for important biomarkers from a large-scale protein profiling in 420 ACS patients and define biomarkers associated with reduced LV function early and 1 year after the ACS. Transferrin receptor protein 1 and NT-proBNP were associated with LV function early and after 1 year, whereas osteopontin and soluble ST2 were associated with LV function in the early phase and, tissue-type plasminogen activator after 1 year. Fatty-acid-binding protein and galectin 3 were related to worse GLS but not to LVEF 1 year after the ACS. Proteins involved in remodeling and iron transport in cardiomyocytes were related to worse LV function after ACS. Biomarkers for energy metabolism and fibrosis were exclusively related to worse LV function by GLS. Studies on the functions of these proteins might add knowledge to the biological processes involved in heart failure in long term after ACS.
引用
收藏
页码：244 / 254
页数：11
相关论文
共 50 条
  • [1] Screening for Biomarkers Associated with Left Ventricular Function During Follow-up After Acute Coronary Syndrome
    Christina Christersson
    Tomasz Baron
    Frank Flachskampf
    Lars Lindhagen
    Bertil Lindahl
    Agneta Siegbahn
    Journal of Cardiovascular Translational Research, 2023, 16 : 244 - 254
  • [2] Coronary microcirculatory dysfunction is associated with left ventricular dysfunction during follow-up after STEMI
    Remmelink, M.
    Sjauw, K. D.
    Yong, Z. Y.
    Haeck, J. D. E.
    Vis, M. M.
    Koch, K. T.
    Tijssen, J. G. P.
    de Winter, R. J.
    Henriques, J. P. S.
    Piek, J. J.
    Baan, J., Jr.
    NETHERLANDS HEART JOURNAL, 2013, 21 (05) : 238 - 244
  • [3] Coronary microcirculatory dysfunction is associated with left ventricular dysfunction during follow-up after STEMI
    M. Remmelink
    K. D. Sjauw
    Z. Y. Yong
    J. D. E. Haeck
    M. M. Vis
    K. T. Koch
    J. G. P. Tijssen
    R. J. de Winter
    J. P. S. Henriques
    J. J. Piek
    J. Baan
    Netherlands Heart Journal, 2013, 21 : 238 - 244
  • [4] The follow-up of myocardial injury and left ventricular function after spontaneous coronary artery dissection
    Krljanac, Gordana
    Apostolovic, Svetlana
    Polovina, Marija
    Maksimovic, Ruzica
    Arsenovic, Olga Nedeljkovic
    Djordjevic, Nemanja
    Stankovic, Stefan
    Savic, Lidija
    Djokovic, Aleksandra
    Viduljevic, Mihajlo
    Stankovic, Sanja
    Asanin, Milika
    FRONTIERS IN CARDIOVASCULAR MEDICINE, 2023, 10
  • [5] SCINTIGRAPHIC ASSESSMENT OF LEFT-VENTRICULAR FUNCTION DURING ACUTE MYOCARDIAL-INFARCTION AND AT FOLLOW-UP
    OLSON, HG
    LYONS, KP
    ARONOW, WS
    ORLANDO, JR
    KUPERUS, J
    TROOP, P
    CLINICAL RESEARCH, 1979, 27 (01): : A9 - A9
  • [6] Three Months Follow-up Patients After Acute Coronary Syndrome
    Loc Vu
    Dung Ho
    Chinh Duc Nguyen
    Thuan Huynh
    Le Anh Do
    Hieu Bui
    Khang Phuc Nguyen
    Tuong Diep
    Quang Minh Mai
    Thach Nguyen
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2024, 83 (16) : S6 - S6
  • [7] Management of hyperglycemia during and in the immediate follow-up of acute coronary syndrome
    El Ouazzani, Jamal
    Ghalem, Amine
    El Ouazzani, Ghizlane
    Ismaili, Nabila
    El Ouafi, Noha
    JOURNAL OF THE SAUDI HEART ASSOCIATION, 2018, 30 (02) : 113 - 121
  • [8] PREDICTORS OF LEFT VENTRICULAR REMODELING IN PATIENT WITH PCI AFTER ACUTE CORONARY SYNDROME IN ONE YEAR FOLLOW UP
    Pylova, T.
    Tseluiko, V.
    ATHEROSCLEROSIS, 2020, 315 : E256 - E256
  • [9] CHANGE IN RENAL FUNCTION DURING EXTENDED FOLLOW-UP AFTER LEFT VENTRICULAR ASSIST DEVICE IMPLANTATION
    Daimee, Usama
    Wang, Meng
    Papernov, Anna
    Sherazi, Saadia
    McNitt, Scott
    Vidula, Himabindu
    Chen, Leway
    Alexis, Jeffrey
    Kutyifa, Valentina
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2017, 69 (11) : 935 - 935
  • [10] Early Recovery of Left Ventricular Function After Revascularization in Acute Coronary Syndrome
    Shenouda, Rafik
    Bytyci, Ibadete
    Sobhy, Mohamed
    Henein, Michael Y.
    JOURNAL OF CLINICAL MEDICINE, 2020, 9 (01)
12345