Resilience conferred by APOE-R136S: a defense bestowed by nature to combat Alzheimer's disease

被引：0
|
作者：
Xiao, Bin [1 ,2 ]
Kuruvilla, Joshua [1 ]
Tan, Eng-King [1 ,2 ,3 ]
机构：
[1] Natl Neurosci Inst, Dept Neurol, Singapore, Singapore
[2] Duke NUS Med Sch, Neurosci Acad Clin Program, Singapore, Singapore
[3] Duke NUS Med Sch, Neurosci & Behav Disorders Program, Singapore, Singapore
来源：
SIGNAL TRANSDUCTION AND TARGETED THERAPY | 2024年 / 9卷 / 01期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1038/s41392-024-01775-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
[No abstract available]
引用
收藏
页数：2
相关论文
共 50 条
  • [1] Resilience conferred by APOE-R136S: a defense bestowed by nature to combat Alzheimer’s disease
    Bin Xiao
    Joshua Kuruvilla
    Eng-King Tan
    Signal Transduction and Targeted Therapy, 9
  • [2] The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation
    Nelson, Maxine R.
    Liu, Peng
    Agrawal, Ayushi
    Yip, Oscar
    Blumenfeld, Jessica
    Traglia, Michela
    Kim, Min Joo
    Koutsodendris, Nicole
    Rao, Antara
    Grone, Brian
    Hao, Yanxia
    Yoon, Seo Yeon
    Xu, Qin
    De Leon, Samuel
    Choenyi, Tenzing
    Thomas, Reuben
    Lopera, Francisco
    Quiroz, Yakeel T.
    Arboleda-Velasquez, Joseph F.
    Reiman, Eric M.
    Mahley, Robert W.
    Huang, Yadong
    NATURE NEUROSCIENCE, 2023, 26 (12) : 2104 - 2121
  • [3] The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation
    Maxine R. Nelson
    Peng Liu
    Ayushi Agrawal
    Oscar Yip
    Jessica Blumenfeld
    Michela Traglia
    Min Joo Kim
    Nicole Koutsodendris
    Antara Rao
    Brian Grone
    Yanxia Hao
    Seo Yeon Yoon
    Qin Xu
    Samuel De Leon
    Tenzing Choenyi
    Reuben Thomas
    Francisco Lopera
    Yakeel T. Quiroz
    Joseph F. Arboleda-Velasquez
    Eric M. Reiman
    Robert W. Mahley
    Yadong Huang
    Nature Neuroscience, 2023, 26 : 2104 - 2121
  • [4] APOE and Alzheimer’s Disease: Evidence Mounts that Targeting APOE4 may Combat Alzheimer’s Pathogenesis
    Md. Sahab Uddin
    Md. Tanvir Kabir
    Abdullah Al Mamun
    Mohamed M. Abdel-Daim
    George E. Barreto
    Ghulam Md Ashraf
    Molecular Neurobiology, 2019, 56 : 2450 - 2465
  • [5] APOE and Alzheimer's Disease: Evidence Mounts that Targeting APOE4 may Combat Alzheimer's Pathogenesis
    Uddin, Md. Sahab
    Kabir, Md. Tanvir
    Al Mamun, Abdullah
    Abdel-Daim, Mohamed M.
    Barreto, George E.
    Ashraf, Ghulam Md
    MOLECULAR NEUROBIOLOGY, 2019, 56 (04) : 2450 - 2465
  • [6] ApoE3 R136S binds to Tau and blocks its propagation, suppressing neurodegeneration in mice with Alzheimer's disease
    Chen, Guiqin
    Wang, Mengmeng
    Zhang, Zhentao
    Hong, Dae Ki
    Ahn, Eun Hee
    Liu, Xia
    Kang, Seong Su
    Ye, Keqiang
    NEURON, 2025, 113 (05)
  • [7] Genetic resilience to Alzheimer's disease in APOE ε4 homozygotes: A systematic review
    Huq, Aamira J.
    Fransquet, Peter
    Laws, Simon M.
    Ryan, Joanne
    Sebra, Robert
    Masters, Colin L.
    Winship, Ingrid M.
    James, Paul A.
    Lacaze, Paul
    ALZHEIMERS & DEMENTIA, 2019, 15 (12) : 1612 - 1623
  • [8] Alzheimer’s disease beyond APOE
    Michael A van Es
    Leonard H van den Berg
    Nature Genetics, 2009, 41 : 1047 - 1048
  • [9] ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease
    Lane-Donovan, Courtney
    Herz, Joachim
    TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2017, 28 (04): : 273 - 284
  • [10] Apoe and memory in Alzheimer's disease
    Soininen, HS
    Riekkinen, PJ
    PROGRESS IN ALZHEIMER'S AND PARKINSON'S DISEASES, 1998, 49 : 13 - 16
12345