IntroductionRwanda stands out in East Africa with the lowest infant mortality ratio at 29 per 1000 live births. It also leads in gender equality on the African continent, ranking sixth globally according to the 2022 Global Gender Gap Report. This makes Rwanda an ideal case for studying the link between women's empowerment and infant mortality.MethodThis study aims to assess the impact of women's empowerment on infant mortality using data obtained from the Rwanda Demographic and Health Survey conducted in 2005, 2010, and 2015. A three-category women's empowerment index was created using the principal component analysis method. The statistical analysis employed in this study is multivariate binary logistic regression. ResultsResults demonstrate a significant impact of women's empowerment on reducing infant mortality, considering regional and residential inequalities, bio-demographic factors, and healthcare variables.ConclusionThe findings contribute to existing literature and highlight the importance of empowering women to improve maternal and child health outcomes. Such empowerment not only enhances health but also supports sustainable development and social progress. Policymakers, healthcare providers, and organizations should prioritize investing in women's empowerment to achieve maternal and child health goals, as empowered women play a pivotal role in driving positive change for a healthier and more equitable society. This study highlights the critical importance of women's empowerment in improving infant survival rates and promoting population health in Rwanda. The study is significant due to the country's low infant mortality rate and leading position in gender equality in Africa. By demonstrating the strong association between women's empowerment and infant mortality, the findings highlight the need for ongoing efforts to empower women and ensure equitable access to healthcare services for all. This research provides valuable insights that can inform policies and programs aimed at reducing infant mortality and enhancing the well-being of both women and children in Rwanda and similar contexts.