Cost-effectiveness of fuzuloparib compared to routine surveillance, niraparib and olaparib for maintenance treatment of patients with germline BRCA1/2 mutation and platinum-sensitive recurrent ovarian carcinoma in China
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作者:
Nie, Jing
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Shandong Second Prov Gen Hosp, Dept Pharm, Jinan, Shandong, Peoples R ChinaShandong Second Prov Gen Hosp, Dept Pharm, Jinan, Shandong, Peoples R China
Nie, Jing
[1
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Wu, Huina
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Shandong Second Prov Gen Hosp, Dept Pharm, Jinan, Shandong, Peoples R ChinaShandong Second Prov Gen Hosp, Dept Pharm, Jinan, Shandong, Peoples R China
Wu, Huina
[1
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Sun, Lei
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Shandong Second Prov Gen Hosp, Dept Pharm, Jinan, Shandong, Peoples R ChinaShandong Second Prov Gen Hosp, Dept Pharm, Jinan, Shandong, Peoples R China
Sun, Lei
[1
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Ding, Yanjiao
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Shandong Second Prov Gen Hosp, Dept Pharm, Jinan, Shandong, Peoples R ChinaShandong Second Prov Gen Hosp, Dept Pharm, Jinan, Shandong, Peoples R China
Ding, Yanjiao
[1
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Luan, Yepeng
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Qingdao Univ, Med Coll, Sch Pharm, Dept Med Chem, Qingdao, Shandong, Peoples R ChinaShandong Second Prov Gen Hosp, Dept Pharm, Jinan, Shandong, Peoples R China
Luan, Yepeng
[2
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Wu, Jiyong
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Shandong Second Prov Gen Hosp, Dept Pharm, Jinan, Shandong, Peoples R ChinaShandong Second Prov Gen Hosp, Dept Pharm, Jinan, Shandong, Peoples R China
Wu, Jiyong
[1
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机构:
[1] Shandong Second Prov Gen Hosp, Dept Pharm, Jinan, Shandong, Peoples R China
[2] Qingdao Univ, Med Coll, Sch Pharm, Dept Med Chem, Qingdao, Shandong, Peoples R China
Background: Maintenance therapy with the poly (ADP-ribose) polymerase inhibitors (PARPis) for platinum-sensitive recurrent ovarian carcinoma (OC) have proven to be effective compared with placebo. We aimed to evaluate the cost-effectiveness (CE) of maintenance fuzuloparib compared to routine surveillance (RS), niraparib and olaparib for platinum-sensitive recurrent OC from the Chinese healthcare systems.Method: A partitioned survival model with three-state (progression-free, progressed, death) was constructed utilizing TreeAge Pro 2011 software to evaluate the economic value of fuzuloparib, niraparib and olaparib maintenance treatment for platinum-sensitive recurrent OC based on the clinical data derived from FZOCUS-2, ENGOT-OV16/NOVA and ENGOT-Ov21/SOLO2. Transition probabilities were estimated from the reported survival probabilities in those trials. Cost and health preference data were derived from the literature. The quality-adjusted life-years (QALYs) and lifetime costs were measured for this analysis. A 5 years horizon and 5%/year discount rates were used. One-way analysis, and probabilistic sensitivity analysis (PSA) were performed to explore the model uncertainties.Results: Total cost of fuzuloparib, niraparib and olaparib were $31628.10, $48183.48 and $54605.54, whereas they had an incremental cost-utility ratio of $31992.69, $32216.08 and $23359.26 per additional progression-free survival (PFS) QALYs gained compared with RS, relatively. Model showed that maintenance fuzuloparib achieved at least an 85.5% probability of CE at the threshold of $37654.50/QALY. One-way sensitivity analysis revealed that the results were sensitive to the PFS and the price of medicines.Conclusion: Fuzuloparib was less cost-effective for patients with germline BRCA1/2 mutation and platinum-sensitive recurrent OC compared to olaparib, but was superior to niraparib from the Chinese healthcare systems perspective.
机构:
Ditmanson Med Fdn, Chiayi Christian Hosp, Dept Obstet & Gynecol, 539 Zhongxiao Rd, Chiayi, TaiwanDitmanson Med Fdn, Chiayi Christian Hosp, Dept Obstet & Gynecol, 539 Zhongxiao Rd, Chiayi, Taiwan
Leung, John Hang
Lang, Hui-Chu
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Natl Yang Ming Chiao Tung Univ, Inst Hosp & Hlth Care Adm, Taipei, TaiwanDitmanson Med Fdn, Chiayi Christian Hosp, Dept Obstet & Gynecol, 539 Zhongxiao Rd, Chiayi, Taiwan
Lang, Hui-Chu
Wang, Shyh-Yau
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机构:
China Med Univ, Annan Hosp, Dept Radiol, Tainan, TaiwanDitmanson Med Fdn, Chiayi Christian Hosp, Dept Obstet & Gynecol, 539 Zhongxiao Rd, Chiayi, Taiwan
Wang, Shyh-Yau
Lo, Hsueh Fang
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Ditmanson Med Fdn, Chiayi Christian Hosp, Dept Obstet & Gynecol, 539 Zhongxiao Rd, Chiayi, TaiwanDitmanson Med Fdn, Chiayi Christian Hosp, Dept Obstet & Gynecol, 539 Zhongxiao Rd, Chiayi, Taiwan
Lo, Hsueh Fang
Chan, Agnes L. F.
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机构:
China Med Univ, Annan Hosp, Dept Pharm, 66,Sec 2,Changhe Rd, Tainan, TaiwanDitmanson Med Fdn, Chiayi Christian Hosp, Dept Obstet & Gynecol, 539 Zhongxiao Rd, Chiayi, Taiwan
机构:
Cent South Univ, Xiangya Hosp, Dept Pharm, Changsha, Peoples R China
Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China
Hunan Inst Pharm Practice & Clin Res, Changsha, Peoples R ChinaCent South Univ, Xiangya Hosp, Dept Pharm, Changsha, Peoples R China
Shi, Yin
Xiao, Di
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Cent South Univ, Xiangya Hosp, Dept Pharm, Changsha, Peoples R China
Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China
Hunan Inst Pharm Practice & Clin Res, Changsha, Peoples R ChinaCent South Univ, Xiangya Hosp, Dept Pharm, Changsha, Peoples R China
Xiao, Di
Li, Shuishi
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Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China
Cent South Univ, Xiangya Hosp, Dept Gen Surg, Changsha, Peoples R ChinaCent South Univ, Xiangya Hosp, Dept Pharm, Changsha, Peoples R China
Li, Shuishi
Liu, Shao
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Cent South Univ, Xiangya Hosp, Dept Pharm, Changsha, Peoples R China
Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China
Hunan Inst Pharm Practice & Clin Res, Changsha, Peoples R ChinaCent South Univ, Xiangya Hosp, Dept Pharm, Changsha, Peoples R China
Liu, Shao
Zhang, Yu
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机构:
Cent South Univ, Xiangya Hosp, Dept Gynecol, Changsha, Peoples R China
Gynecol Oncol Res & Engn Ctr Hunan Prov, Changsha, Peoples R ChinaCent South Univ, Xiangya Hosp, Dept Pharm, Changsha, Peoples R China
机构:
China Pharmaceut Univ, Sch Int Pharmaceut Business, Nanjing, Peoples R ChinaChina Pharmaceut Univ, Sch Int Pharmaceut Business, Nanjing, Peoples R China
Qiu, Yijin
Zha, Jingkai
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机构:
China Pharmaceut Univ, Sch Int Pharmaceut Business, Nanjing, Peoples R ChinaChina Pharmaceut Univ, Sch Int Pharmaceut Business, Nanjing, Peoples R China
Zha, Jingkai
Ma, Aixia
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机构:
China Pharmaceut Univ, Sch Int Pharmaceut Business, Nanjing, Peoples R ChinaChina Pharmaceut Univ, Sch Int Pharmaceut Business, Nanjing, Peoples R China
Ma, Aixia
Zhou, Ting
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机构:
China Pharmaceut Univ, Sch Int Pharmaceut Business, Nanjing, Peoples R ChinaChina Pharmaceut Univ, Sch Int Pharmaceut Business, Nanjing, Peoples R China
机构:
Duke Univ, Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol,Duke Canc Inst, Durham, NC 27710 USADuke Univ, Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol,Duke Canc Inst, Durham, NC 27710 USA
Secord, Angeles Alvarez
Barnett, Jason Cory
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机构:
Brooke Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Ft Sam Houston, TX 78234 USADuke Univ, Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol,Duke Canc Inst, Durham, NC 27710 USA
Barnett, Jason Cory
Ledermann, Jonathan A.
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机构:
UCL Canc Inst, London, England
Biomed Res Ctr, London, EnglandDuke Univ, Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol,Duke Canc Inst, Durham, NC 27710 USA
Ledermann, Jonathan A.
Peterson, Bercedis L.
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机构:
Duke Univ, Med Ctr, Dept Biostat & Bioinformat, Durham, NC 27710 USADuke Univ, Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol,Duke Canc Inst, Durham, NC 27710 USA
Peterson, Bercedis L.
Myers, Evan R.
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机构:
Duke Univ, Med Ctr, Dept Obstet & Gynecol, Div Clin & Epidemiol Res, Durham, NC 27710 USADuke Univ, Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol,Duke Canc Inst, Durham, NC 27710 USA
Myers, Evan R.
Havrilesky, Laura J.
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机构:
Duke Univ, Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol,Duke Canc Inst, Durham, NC 27710 USADuke Univ, Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol,Duke Canc Inst, Durham, NC 27710 USA