SARS-CoV-2 IgG seroprevalence surveys in blood donors before the vaccination campaign, France 2020-2021

We conducted a cross-sectional study for SARS-CoV-2 anti-S1 IgG prevalence in French blood donors (n = 32605), from March-2020 to January-2021. A mathe-matical model combined seroprevalence with a daily number of hospital admis-sions to estimate the probability of hospitalization upon infection and determine the number of infections while correcting for antibody decay. There was an over-all seroprevalence increase over the study period and we estimate that -15% of the French population had been infected by SARS-CoV-2 by January-2021. The infection/hospitalization ratio increased with age, from 0.31% (18-30yo) to 4.5% (61-70yo). Half of the IgG-S1 positive individuals had no detectable anti-bodies 4 to 5 months after infection. The seroprevalence in group O donors (7.43%) was lower (p = 0.003) than in A, B, and AB donors (8.90%). We conclude, based on seroprevalence data and mathematical modeling, that a large propor-tion of the French population was unprotected against severe disease prior to the vaccination campaign.