Hands-on Synthetic Approaches and Biological Activities of Anthranilic Acid Derivatives: A mini-review

Anthranilic acid scaffold is a pivotal class of amino organic acids used for the construction of many organic candidates exhibiting a wide range of industrial, pharmaceutical, and biological activities. In addition, anthranilic acid derivatives are considered a cheap and efficient stating precursor for the production and synthesis of various marketed available drugs like furosemide (diuretic), tranilast (antiallergic), betrixaban (anticoagulant) and analgesic & anti-inflammatory fenamates. Furthermore, numerous anthranilic acid analogs with potential anticancer, antimicrobial, insecticidal, antiviral, anti-inflammatory activities and other biological activities have been disclosed over the last thirty years. The current review represents a brief and simple summary of different synthetic methodologies and techniques applied for the construction and synthesis of different anthranilic acid analogs and derivatives along with a concise discussion of the potential therapeutic activity of these synthesized derivatives.