Nickel/Titanocene-Catalyzed Electrophilic Acylation Coupling of Styrene Oxides

被引：3
|
作者：
Li, Jincan [1 ]
Cao, Chang [1 ]
Wu, Haihong [1 ]
Dong, Kaiwu [2 ]
机构：
[1] East China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Sch Chem & Mol Engn, Shanghai 200062, Peoples R China
[2] East China Normal Univ, Shanghai Frontiers Sci Ctr Mol Intelligent Synthe, Sch Chem & Mol Engn, Shanghai 200062, Peoples R China
来源：
ORGANIC LETTERS | 2023年 / 25卷 / 38期
关键词：
C(SP(3))-H BONDS; KETONE SYNTHESIS; ALKYL-HALIDES; ARYL HALIDES; NICKEL; CARBOACYLATION; ANHYDRIDES; EPOXIDES; ACIDS; MILD;
D O I：
10.1021/acs.orglett.3c02402
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The cross-coupling of epoxides with acyl chlorides or anhydrides by a nickel/titanocene dual catalytic system is established. A variety of synthetically useful beta-hydroxy ketones were obtained in good to high yields by using modified pyridine-oxazoline ligand. The reaction proceeds via the cooperation of titanocene-catalyzed ring-opening of epoxides and nickel-catalyzed acylation of the benzylic radical intermediate.
引用
收藏
页码：6959 / 6963
页数：5
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